Targeting INHBA in Ovarian Cancer Cells Suppresses Cancer Xenograft Growth by Attenuating Stromal Fibroblast Activation
Joint Authors
Li, Xiaoting
Yang, Zongyuan
Xu, Sen
Wang, Zhengzheng
Jin, Ping
Yang, Xin
Zhang, Zeyu
Wang, Ya
Wei, Xiao
Fang, Tian
Gao, Qinglei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
INHBA-encoded inhibin β A is a member of the transforming growth factor-β (TGF-β) superfamily.
INHBA has been reported to be implicated in the progression of multiple types of cancer including ovarian cancer (OC).
However, the mechanisms by which INHBA affects OC progression are not well-characterized.
The aim of our study was to explore the prognostic value of INHBA for different stages and grades of OC and to identify the possible mechanisms by which INHBA promotes OC progression.
Our results demonstrated that INHBA was specifically expressed in OC epithelium, and higher expression was associated with higher risk of mortality in patients with advanced and higher-grade serous OC (SOC).
In addition, knockdown of INHBA in cancer cells impaired cancer xenograft growth through reducing OC stromal fibroblast activation in vivo.
Further results confirmed that Smad2 signaling pathway was involved in INHBA-induced stromal fibroblast activation, and inhibiting this pathway could effectively reverse activation of stromal fibroblasts.
In summary, our results showed that blocking INHBA in cancer cells may be a potential therapeutic strategy to inhibit SOC progression.
American Psychological Association (APA)
Li, Xiaoting& Yang, Zongyuan& Xu, Sen& Wang, Zhengzheng& Jin, Ping& Yang, Xin…[et al.]. 2019. Targeting INHBA in Ovarian Cancer Cells Suppresses Cancer Xenograft Growth by Attenuating Stromal Fibroblast Activation. Disease Markers،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1147690
Modern Language Association (MLA)
Li, Xiaoting…[et al.]. Targeting INHBA in Ovarian Cancer Cells Suppresses Cancer Xenograft Growth by Attenuating Stromal Fibroblast Activation. Disease Markers No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1147690
American Medical Association (AMA)
Li, Xiaoting& Yang, Zongyuan& Xu, Sen& Wang, Zhengzheng& Jin, Ping& Yang, Xin…[et al.]. Targeting INHBA in Ovarian Cancer Cells Suppresses Cancer Xenograft Growth by Attenuating Stromal Fibroblast Activation. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1147690
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147690