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A Case Report with Severe Thrombocytopenia Induced by Axitinib
Joint Authors
Koksal, Ulkuhan I.
Goffin, Janeiro Valle
Lewis, Brian
Sartor, Oliver A.
Belyaeva, Elizaveta
Socola, Francisco
Barata, Pedro C.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-07
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Axitinib is an oral, second-generation tyrosine kinase inhibitor that is selective for vascular endothelial growth factor receptors (VEGFR).
This agent is approved as monotherapy or in combination with immune checkpoint inhibitors for the treatment of metastatic renal cell carcinoma.
Axitinib is associated with a safety profile very similar to other anti-VEGFR inhibitors but usually with fewer hematologic adverse events, due to the selectivity for VEGF.
In this report, we presented a rare case of grade 4 axitinib-induced thrombocytopenia, not observed with other antiangiogenic therapies.
We discuss the differential diagnostic work-up, the necessary multidisciplinary approach, and the successful management of the case.
American Psychological Association (APA)
Koksal, Ulkuhan I.& Goffin, Janeiro Valle& Lewis, Brian& Sartor, Oliver A.& Belyaeva, Elizaveta& Socola, Francisco…[et al.]. 2020. A Case Report with Severe Thrombocytopenia Induced by Axitinib. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147713
Modern Language Association (MLA)
Koksal, Ulkuhan I.…[et al.]. A Case Report with Severe Thrombocytopenia Induced by Axitinib. Case Reports in Hematology No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1147713
American Medical Association (AMA)
Koksal, Ulkuhan I.& Goffin, Janeiro Valle& Lewis, Brian& Sartor, Oliver A.& Belyaeva, Elizaveta& Socola, Francisco…[et al.]. A Case Report with Severe Thrombocytopenia Induced by Axitinib. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147713