Severe Aplastic Anemia Developed after Thymectomy: A Case Report and Literature Review
Joint Authors
Gouveia, Pedro Alves da Cruz
Duarte Rodrigues, Bruna Cristine
Freire, Pedro José Galvão
Campos, Beatriz Pinto e Siqueira
Vieira, Juliana Oliveira
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-13
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Thymus neoplasms are frequently related to paraneoplastic autoimmune manifestations.
Its most common associations are myasthenia gravis and pure red cell aplasia.
Aplastic anemia has been increasingly documented as an initial presentation of thymoma.
Nevertheless, its development after successful surgical resection of thymoma is a rare condition.
We report a case of a 53-year-old man with severe aplastic anemia preceded by amegakaryocytic thrombocytopenia three years after thymectomy with no signs of disease recurrence.
He underwent immunosuppressive therapy with cyclosporine 5 mg/kg/day and prednisone 2 mg/kg/day for six weeks.
Considering the availability of a compatible donor, allogeneic stem cell transplantation was carried out.
However, the patient died 11 days after transplant.
A literature review was conducted, and another ten cases of aplastic anemia, diagnosed three months to four years after thymectomy, were identified.
These cases suggest persistence of peripheral self-reactive T lymphocytes even years after tumor definitive treatment.
American Psychological Association (APA)
Duarte Rodrigues, Bruna Cristine& Freire, Pedro José Galvão& Campos, Beatriz Pinto e Siqueira& Vieira, Juliana Oliveira& Gouveia, Pedro Alves da Cruz. 2020. Severe Aplastic Anemia Developed after Thymectomy: A Case Report and Literature Review. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147716
Modern Language Association (MLA)
Duarte Rodrigues, Bruna Cristine…[et al.]. Severe Aplastic Anemia Developed after Thymectomy: A Case Report and Literature Review. Case Reports in Hematology No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1147716
American Medical Association (AMA)
Duarte Rodrigues, Bruna Cristine& Freire, Pedro José Galvão& Campos, Beatriz Pinto e Siqueira& Vieira, Juliana Oliveira& Gouveia, Pedro Alves da Cruz. Severe Aplastic Anemia Developed after Thymectomy: A Case Report and Literature Review. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147716
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147716