Histoplasma capsulatum Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient Receiving Voriconazole Prophylaxis

Abstract EN

Histoplasma capsulatum infection is a rare complication in the allogeneic stem cell transplant patients.

Minimal guidance exists on how to appropriately manage histoplasmosis in these patients.

We report a patient who developed Histoplasma pneumonia while receiving voriconazole prophylaxis at a therapeutic trough level.

The patient experienced significant clinical improvement after initiation of itraconazole pharmacotherapy.

We recommend a lower threshold for evaluation for histoplasmosis in allogeneic hematopoietic stem cell transplant recipients who live in endemic regions, regardless of their antifungal prophylactic regimen.