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Rituximab Monotherapy in the Management of a Rare Case of an HIV Associated Lymphoproliferative Disorder
Joint Authors
Hew, Jason
Zhou, Louise
Rana, Fauzia
Source
Case Reports in Oncological Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Castleman’s disease (CD), also known as angiofollicular node hyperplasia, is a rare heterogenous lymphoproliferative disorder.
This disease exists as two distinct entities: a localized or unicentric CD (UCD) which has a more benign clinical course and multicentric CD (MCD) which is a systemic disease and carries a worse prognosis.
MCD is often associated with human immunodeficiency virus (HIV) infection and these patients are usually coinfected with human herpes virus-8 (HHV-8).
Rituximab is an anti-CD20 monoclonal antibody that has become integral to the management of this disease.
It is used alone or in combination with chemotherapy to treat MCD.
Case Report.
We describe a case of a 58-year-old man with HIV and HHV-8 MCD and evidence of organ failure with a poor performance status that went into complete remission after four cycles of therapy with weekly rituximab.
Conclusion.
HIV-MCD can be challenging to diagnose and to manage.
Early recognition can reduce morbidity and mortality associated with the disease.
Rituximab monotherapy can be used as a safe and effective treatment option in patients with a poor performance status.
American Psychological Association (APA)
Hew, Jason& Rana, Fauzia& Zhou, Louise. 2017. Rituximab Monotherapy in the Management of a Rare Case of an HIV Associated Lymphoproliferative Disorder. Case Reports in Oncological Medicine،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1147736
Modern Language Association (MLA)
Hew, Jason…[et al.]. Rituximab Monotherapy in the Management of a Rare Case of an HIV Associated Lymphoproliferative Disorder. Case Reports in Oncological Medicine No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1147736
American Medical Association (AMA)
Hew, Jason& Rana, Fauzia& Zhou, Louise. Rituximab Monotherapy in the Management of a Rare Case of an HIV Associated Lymphoproliferative Disorder. Case Reports in Oncological Medicine. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1147736
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147736