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Aggressive Central Nervous System Relapse after Autologous Stem Cell Transplant in Multiple Myeloma: Case Reports and Literature Review
Joint Authors
Marques, C.
Bergantim, Rui
Bastos, Juliana
Soares, Maria José
Soares, Pedro
Costa, Jennifer
Guimarães, José Eduardo
Trigo, Fernanda
Carvalho, Bruno
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Extramedullary disease is an aggressive presentation at diagnosis and relapse for multiple myeloma (MM) patients.
Central nervous system (CNS) is a very rare manifestation of the extramedullary disease, accounting for less than 1% of MM on diagnosis and relapse.
Neurological symptoms are unspecific and usually attributed to other causes.
We present two patients with CNS-MM at relapse after autologous stem cell transplant highlighting the importance of clinical suspicion and interdisciplinarity at diagnostic workup as well as the need for intensive therapeutic options on such rare and aggressive cases.
The presence of neurological abnormalities in anamnesis and physical examination on a patient with MM should always prompt to suspect of a CNS involvement, and active investigation must be undertaken.
MRI is the standard radiological method to detect CNS-MM, with histopathological corroboration by stereotactic biopsy and CSF evaluation alongside.
Treatment of CNS-MM should include two essential approaches—be able to cross the BBB and treat the systemic disease.
There is no standard therapy for this extramedullary relapse, and a tailored and multiple therapy should be promptly started—intrathecal therapy, radiotherapy, and systemic therapy, including an immunomodulator.
American Psychological Association (APA)
Bergantim, Rui& Bastos, Juliana& Soares, Maria José& Carvalho, Bruno& Soares, Pedro& Marques, C.…[et al.]. 2020. Aggressive Central Nervous System Relapse after Autologous Stem Cell Transplant in Multiple Myeloma: Case Reports and Literature Review. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1147749
Modern Language Association (MLA)
Bergantim, Rui…[et al.]. Aggressive Central Nervous System Relapse after Autologous Stem Cell Transplant in Multiple Myeloma: Case Reports and Literature Review. Case Reports in Hematology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1147749
American Medical Association (AMA)
Bergantim, Rui& Bastos, Juliana& Soares, Maria José& Carvalho, Bruno& Soares, Pedro& Marques, C.…[et al.]. Aggressive Central Nervous System Relapse after Autologous Stem Cell Transplant in Multiple Myeloma: Case Reports and Literature Review. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1147749
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147749