Biomarkers of Inflammation in Left Ventricular Diastolic Dysfunction
Joint Authors
Mocan, Mihaela
Mocan Hognogi, Larisa Diana
Anton, Florin Petru
Chiorescu, Roxana Mihaela
Goidescu, Cerasela Mihaela
Stoia, Mirela Anca
Farcas, Anca Daniela
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-02
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Left ventricular diastolic dysfunction (LVDD) is an important precursor to many different cardiovascular diseases.
Diastolic abnormalities have been studied extensively in the past decade, and it has been confirmed that one of the mechanisms leading to heart failure is a chronic, low-grade inflammatory reaction.
The triggers are classical cardiovascular risk factors, grouped under the name of metabolic syndrome (MetS), or other systemic diseases that have an inflammatory substrate such as chronic obstructive pulmonary disease.
The triggers could induce myocardial apoptosis and reduce ventricular wall compliance through the release of cytokines by multiple pathways such as (1) immune reaction, (2) prolonged cell hypoxemia, or (3) excessive activation of neuroendocrine and autonomic nerve function disorder.
The systemic proinflammatory state causes coronary microvascular endothelial inflammation which reduces nitric oxide bioavailability, cyclic guanosine monophosphate content, and protein kinase G (PKG) activity in adjacent cardiomyocytes favoring hypertrophy development and increases resting tension.
So far, it has been found that inflammatory cytokines associated with the heart failure mechanism include TNF-α, IL-6, IL-8, IL-10, IL-1α, IL-1β, IL-2, TGF-β, and IFN-γ.
Some of them could be used as diagnosis biomarkers.
The present review aims at discussing the inflammatory mechanisms behind diastolic dysfunction and their triggering conditions, cytokines, and possible future inflammatory biomarkers useful for diagnosis.
American Psychological Association (APA)
Mocan, Mihaela& Mocan Hognogi, Larisa Diana& Anton, Florin Petru& Chiorescu, Roxana Mihaela& Goidescu, Cerasela Mihaela& Stoia, Mirela Anca…[et al.]. 2019. Biomarkers of Inflammation in Left Ventricular Diastolic Dysfunction. Disease Markers،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1147762
Modern Language Association (MLA)
Mocan, Mihaela…[et al.]. Biomarkers of Inflammation in Left Ventricular Diastolic Dysfunction. Disease Markers No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1147762
American Medical Association (AMA)
Mocan, Mihaela& Mocan Hognogi, Larisa Diana& Anton, Florin Petru& Chiorescu, Roxana Mihaela& Goidescu, Cerasela Mihaela& Stoia, Mirela Anca…[et al.]. Biomarkers of Inflammation in Left Ventricular Diastolic Dysfunction. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1147762
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147762