Prognostic Significance of the Lymphocyte-to-Monocyte Ratio in Bladder Cancer Undergoing Radical Cystectomy: A Meta-Analysis of 5638 Individuals
Joint Authors
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
A growing number of studies have explored the association between the pretreatment lymphocyte-to-monocyte ratio (LMR) and survival outcomes in various cancers.
However, its prognostic significance on bladder cancer remains inconsistent.
The aim of this meta-analysis was to evaluate the prognostic value of pretreatment LMR in bladder cancer.
Methods.
The MEDLINE, EMBASE, Cochrane Library, and CNKI databases were comprehensively searched for relevant studies.
A meta-analysis of overall survival (OS), recurrence-free survival (RFS), or cancer-specific survival (CSS) clinicopathological features was conducted.
Results.
Nine studies containing 5,638 cancer patients were analyzed in this meta-analysis.
Patients with high LMR tended to have favourable OS (HR: 0.63, 95% CI: 0.50-0.80, P<0.001), RFS (HR: 0.59, 95% CI: 0.38-0.91, P=0.017), and CSS (HR: 0.76, 95% CI: 0.70-0.83, P<0.001).
Moreover, low LMR was highly correlated with age (≥60), differentiation (low), T stage (III-IV), lymph node metastasis (yes), and concomitant Cis (yes).
Conclusion.
Pretreatment LMR might be a useful predictor of survival outcomes in patients with bladder cancer.
American Psychological Association (APA)
Ma, Jian-ying& Hu, Gang& Liu, Qin. 2019. Prognostic Significance of the Lymphocyte-to-Monocyte Ratio in Bladder Cancer Undergoing Radical Cystectomy: A Meta-Analysis of 5638 Individuals. Disease Markers،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147769
Modern Language Association (MLA)
Ma, Jian-ying…[et al.]. Prognostic Significance of the Lymphocyte-to-Monocyte Ratio in Bladder Cancer Undergoing Radical Cystectomy: A Meta-Analysis of 5638 Individuals. Disease Markers No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1147769
American Medical Association (AMA)
Ma, Jian-ying& Hu, Gang& Liu, Qin. Prognostic Significance of the Lymphocyte-to-Monocyte Ratio in Bladder Cancer Undergoing Radical Cystectomy: A Meta-Analysis of 5638 Individuals. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147769
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147769