Venetoclax and Decitabine for TMyeloid Mixed-Phenotype Acute Leukemia Not Otherwise Specified (MPAL NOS)
Joint Authors
Chauncey, Thomas R.
Burwick, Nicholas
Klocke, Heather
Dong, Zhao Ming
O’Brien, Craig
Richard, Robert E.
Wu, Daniel Y.
Graf, Solomon A.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-10
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
T/myeloid mixed-phenotype acute leukemia not otherwise specified (MPAL NOS) is an uncommon and aggressive leukemia without well-established treatment guidelines, particularly when relapsed.
Venetoclax plus a hypomethylating agent offers a promising option in this situation since studies support its use in both acute myeloid and, albeit with fewer data to date, acute T-cell-lymphoblastic leukemias.
We report the successful eradication of T/myeloid MPAL NOS relapsed after allogeneic stem cell transplant with venetoclax plus decitabine.
A consolidative allogeneic stem cell transplant from a second donor was subsequently performed, and the patient remained without evidence of disease more than one year later.
Further investigation is indicated to evaluate venetoclax combined with hypomethylating agents and/or other therapies for the management of T/myeloid MPAL NOS.
American Psychological Association (APA)
Klocke, Heather& Dong, Zhao Ming& O’Brien, Craig& Burwick, Nicholas& Richard, Robert E.& Wu, Daniel Y.…[et al.]. 2020. Venetoclax and Decitabine for TMyeloid Mixed-Phenotype Acute Leukemia Not Otherwise Specified (MPAL NOS). Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147773
Modern Language Association (MLA)
Klocke, Heather…[et al.]. Venetoclax and Decitabine for TMyeloid Mixed-Phenotype Acute Leukemia Not Otherwise Specified (MPAL NOS). Case Reports in Hematology No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1147773
American Medical Association (AMA)
Klocke, Heather& Dong, Zhao Ming& O’Brien, Craig& Burwick, Nicholas& Richard, Robert E.& Wu, Daniel Y.…[et al.]. Venetoclax and Decitabine for TMyeloid Mixed-Phenotype Acute Leukemia Not Otherwise Specified (MPAL NOS). Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147773
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147773