Rapid Response in a Patient with RelapsedRefractory Multiple Myeloma Treated with BRAFMEK Inhibitors
Joint Authors
Otieno, Steve Biko
Nasir, Syed
Weir, Alva
Johnson, Robert
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-11
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Patients with relapsed and refractory multiple myeloma have a poor prognosis.
The mitogen-activated protein kinase (MAPK) pathway has been implicated in the pathogenesis of multiple myeloma.
Several mutations in this pathway can lead to its constitutive activation leading to oncogenesis.
One such mutation is BRAFV600E which is a therapeutic target in the treatment of melanoma, lung cancer, colon cancer, thyroid cancer, and hairy cell leukemia.
BRAFV600E-directed therapy currently does not have approval in multiple myeloma.
It has been proposed that this mutation leads to proteasome inhibitor resistance.
About 4–10% of multiple myeloma cases harbor the BRAFV600E mutation.
Herein, we report a case of a patient with relapsed and refractory multiple myeloma who had a progression-free survival (PFS) of 8.5 months on BRAF-targeted therapy.
American Psychological Association (APA)
Otieno, Steve Biko& Nasir, Syed& Weir, Alva& Johnson, Robert. 2020. Rapid Response in a Patient with RelapsedRefractory Multiple Myeloma Treated with BRAFMEK Inhibitors. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147791
Modern Language Association (MLA)
Otieno, Steve Biko…[et al.]. Rapid Response in a Patient with RelapsedRefractory Multiple Myeloma Treated with BRAFMEK Inhibitors. Case Reports in Hematology No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1147791
American Medical Association (AMA)
Otieno, Steve Biko& Nasir, Syed& Weir, Alva& Johnson, Robert. Rapid Response in a Patient with RelapsedRefractory Multiple Myeloma Treated with BRAFMEK Inhibitors. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147791
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147791