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Clinical Application of Liquid Biopsy in Targeted Therapy of Metastatic Colorectal Cancer
Joint Authors
Trojan, Jörg
Klein-Scory, Susanne
Koch, Christine
Schmiegel, Wolff
Baraniskin, Alexander
Source
Case Reports in Oncological Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-23
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Background.
Colorectal cancers (CRC) shed DNA into blood circulation.
There is growing evidence that the analysis of circulating tumor DNA can be effectively used for monitoring of disease, to track tumor heterogeneity and to evaluate response to treatment.
Case Presentation.
Here, we describe two cases of patients with advanced CRC.
The first case is about a patient with no available tissue for analysis of RAS mutation status.
Liquid biopsy revealed RAS-wild-type and the therapy with anti-EGFR (epidermal growth factor receptor) monoclonal antibody cetuximab could be initiated.
In the second case, the mutational profile of a patient with initial wild-type RAS-status was continually tracked during the course of treatment.
An acquired KRAS exon 3 mutation was detected.
The number of KRAS mutated fragments decreased continuously after the discontinuation of the therapy with EGFR-specific antibodies.
Conclusion.
Liquid biopsy provides a rapid genotype result, which accurately reproduces the current mutation status of tumor tissue.
Furthermore, liquid biopsy enables close monitoring of the onset of secondary resistance to anti-EGFR therapy.
American Psychological Association (APA)
Trojan, Jörg& Klein-Scory, Susanne& Koch, Christine& Schmiegel, Wolff& Baraniskin, Alexander. 2017. Clinical Application of Liquid Biopsy in Targeted Therapy of Metastatic Colorectal Cancer. Case Reports in Oncological Medicine،Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1147799
Modern Language Association (MLA)
Trojan, Jörg…[et al.]. Clinical Application of Liquid Biopsy in Targeted Therapy of Metastatic Colorectal Cancer. Case Reports in Oncological Medicine No. 2017 (2017), pp.1-3.
https://search.emarefa.net/detail/BIM-1147799
American Medical Association (AMA)
Trojan, Jörg& Klein-Scory, Susanne& Koch, Christine& Schmiegel, Wolff& Baraniskin, Alexander. Clinical Application of Liquid Biopsy in Targeted Therapy of Metastatic Colorectal Cancer. Case Reports in Oncological Medicine. 2017. Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1147799
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147799