PML-RARA Fusion Transcripts Detectable 8 Months prior to Promyelocytic Blast Crisis in Chronic Myeloid Leukemia
Joint Authors
Beaty, Michael W.
Pettenati, Mark J.
Powell, Bayard L.
Insuasti-Beltran, Giovanni
Wolanin, Stephanie
McCall, Robert K.
O’Neill, Stacey S.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Promyelocytic blast crisis arising from chronic myeloid leukemia (CML) is rare.
We present a 40-year-old male who developed promyelocytic blast crisis 17 months after CML diagnosis, confirmed by the presence of the t(15;17) and t(9;22) translocations in the leukemic cells.
Preserved nucleic acids from routine BCR-ABL1 testing provided a unique opportunity to evaluate clonal progression over time.
Retrospective analysis demonstrated PML-RARA fusion transcripts were first detectable 8 months prior to blast crisis presentation.
A review of 21 cases of promyelocytic blasts crisis published in the literature reveals a male predominance with earlier age at onset as compared to females.
Interestingly, TKI therapy during chronic phase did not impact the time interval between diagnosis and promyelocytic blast crisis.
Treatment with standard acute promyelocytic leukemia regimens provides more favorable outcomes with complete molecular remission.
Although rare, it is important to consider a promyelocytic blast crisis when evaluating for transformation of CML due to its effective treatment with specific therapies.
American Psychological Association (APA)
Wolanin, Stephanie& McCall, Robert K.& Pettenati, Mark J.& Beaty, Michael W.& Insuasti-Beltran, Giovanni& Powell, Bayard L.…[et al.]. 2020. PML-RARA Fusion Transcripts Detectable 8 Months prior to Promyelocytic Blast Crisis in Chronic Myeloid Leukemia. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1147816
Modern Language Association (MLA)
Wolanin, Stephanie…[et al.]. PML-RARA Fusion Transcripts Detectable 8 Months prior to Promyelocytic Blast Crisis in Chronic Myeloid Leukemia. Case Reports in Hematology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1147816
American Medical Association (AMA)
Wolanin, Stephanie& McCall, Robert K.& Pettenati, Mark J.& Beaty, Michael W.& Insuasti-Beltran, Giovanni& Powell, Bayard L.…[et al.]. PML-RARA Fusion Transcripts Detectable 8 Months prior to Promyelocytic Blast Crisis in Chronic Myeloid Leukemia. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1147816
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147816