Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review
Joint Authors
Herford, Alan Scott
Cervino, G.
Troiano, Giuseppe
De Stefano, Rosa
D’Amico, Cesare
Fiorillo, Luca
Bianchi, Alberto
Santoro, Rossella
Laino, Luigi
Laino, Gregorio
Cicciù, Marco
Crimi, Salvatore
Umberto, Romeo
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Backgrounds.
The objective of the present research was to systematically revise the international literature about the genetic biomarkers related to oral cancer (OC) evaluating the recent findings in clinical studies.
Methods.
A comprehensive review of the current literature was conducted according to the PRISMA guidelines by accessing the NCBI PubMed database.
The authors conducted the search of articles in the English language published from 2008 to 2018.
The present systematic review included only papers with significant results about correlation between wound healing, genetic alteration, and OC.
Prognostic capacity of genetic markers was not evaluated in vivo.
Results.
The first analysis with filters recorded about 1884 published papers.
Beyond reading and consideration of suitability, only 20 and then 8 papers, with case report exclusion, were recorded for the revision.
Conclusion.
All the researches recorded the proteomic and genetic alterations in OC human biopsy cells.
The gene modification level in the different studies, compared with samples of healthy tissues, has always been statistically significant, but it is not possible to associate publications with each other because each job is based on the measurement of different biomarkers and gene targets.
Further investigations should be required in order to state scientific evidence about a clear advantage of using these biomarkers for diagnostic purpose.
American Psychological Association (APA)
Cervino, G.& Fiorillo, Luca& Herford, Alan Scott& Umberto, Romeo& Bianchi, Alberto& Crimi, Salvatore…[et al.]. 2019. Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review. Disease Markers،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1147823
Modern Language Association (MLA)
Cervino, G.…[et al.]. Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review. Disease Markers No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1147823
American Medical Association (AMA)
Cervino, G.& Fiorillo, Luca& Herford, Alan Scott& Umberto, Romeo& Bianchi, Alberto& Crimi, Salvatore…[et al.]. Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1147823
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147823