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A Rare Presentation of Isolated CNS Posttransplantation Lymphoproliferative Disorder
Joint Authors
Morris, Jaime
Smith, Casey
Streicher, Andrew
Magnuson, Allison
Newman, Susan
Bertoli, Robert
Source
Case Reports in Oncological Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Posttransplantation lymphoproliferative disorder (PTLD) is a recognized and extremely morbid complication of solid organ transplantation, but central nervous system involvement, particularly in isolation, is rare.
There are no standardized treatment strategies for PTLD, though commonly used strategies include reduction of immunosuppression, chemotherapy, rituximab, radiation, and surgery.
We present a case of an unusual morphologic variant of primary central nervous system PTLD with successful response to rituximab and cranial radiation.
A 69-year-old Asian male, who underwent postrenal transplant nine years earlier, presented with a one-month history of new onset seizure activity.
His evaluation revealed multiple brain lesions on magnetic resonance imaging (MRI), as well as serologic and cerebrospinal fluid studies which were positive for Epstein-Barr Virus (EBV) infection.
Ultimately, he underwent craniotomy with tissue biopsy with the final pathology report showing posttransplant lymphoproliferative disorder, polymorphic type.
The patient was managed with reduction in immunosuppression, rituximab therapy, and cranial radiation treatments.
He had demonstrated marked improvement in his neurologic function and was ultimately discharged to inpatient rehabilitation facility.
American Psychological Association (APA)
Morris, Jaime& Smith, Casey& Streicher, Andrew& Magnuson, Allison& Newman, Susan& Bertoli, Robert. 2017. A Rare Presentation of Isolated CNS Posttransplantation Lymphoproliferative Disorder. Case Reports in Oncological Medicine،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1147829
Modern Language Association (MLA)
Morris, Jaime…[et al.]. A Rare Presentation of Isolated CNS Posttransplantation Lymphoproliferative Disorder. Case Reports in Oncological Medicine No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1147829
American Medical Association (AMA)
Morris, Jaime& Smith, Casey& Streicher, Andrew& Magnuson, Allison& Newman, Susan& Bertoli, Robert. A Rare Presentation of Isolated CNS Posttransplantation Lymphoproliferative Disorder. Case Reports in Oncological Medicine. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1147829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147829