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Profound Sinoatrial Arrest Associated with Ibrutinib
Joint Authors
Mathur, Kanupriya
Saini, Aditya
Ellenbogen, Kenneth A.
Shepard, Richard K.
Source
Case Reports in Oncological Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-10
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Background.
Ibrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for second-line treatment for mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), and Waldenström macroglobulinemia.
Ibrutinib use has been linked to increased incidence of atrial fibrillation and hypertension in multiple studies.
Other forms of cardiac toxicities have also been reported in isolated case reports.
Bradycardia and asystole have not been associated with ibrutinib use in the past.
Case Report.
We present a case of a 76-year-old female with no prior cardiac history, who initiated treatment with ibrutinib for relapsing mantle cell lymphoma and was noted to have symptomatic bradycardia, greater than 20 second long pauses on her cardiac monitor requiring placement of a permanent pacemaker.
Conclusion.
This is the first case associating bradycardia and asystole with tyrosine kinase inhibitor use.
Irreversible inhibition of certain cardioprotective tyrosine kinases has been a growing topic of research in oncology therapeutics.
American Psychological Association (APA)
Mathur, Kanupriya& Saini, Aditya& Ellenbogen, Kenneth A.& Shepard, Richard K.. 2017. Profound Sinoatrial Arrest Associated with Ibrutinib. Case Reports in Oncological Medicine،Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1147834
Modern Language Association (MLA)
Mathur, Kanupriya…[et al.]. Profound Sinoatrial Arrest Associated with Ibrutinib. Case Reports in Oncological Medicine No. 2017 (2017), pp.1-3.
https://search.emarefa.net/detail/BIM-1147834
American Medical Association (AMA)
Mathur, Kanupriya& Saini, Aditya& Ellenbogen, Kenneth A.& Shepard, Richard K.. Profound Sinoatrial Arrest Associated with Ibrutinib. Case Reports in Oncological Medicine. 2017. Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1147834
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147834