Decreased Levels of Histidine-Rich Glycoprotein in Advanced Lung Cancer: Association with Prothrombotic Alterations
Joint Authors
Undas, Anetta
Winiarska, Aleksandra
Zareba, Lech
Krolczyk, Grzegorz
Czyzewicz, Grzegorz
Zabczyk, Michal
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Histidine-rich glycoprotein (HRG) displays anticoagulant and antifibrinolytic properties in animal models, but its effects in humans are unclear.
We investigated serum HRG levels and their associations with the disease stage and prothrombotic alterations in lung cancer (LC) patients.
Methods.
In 148 patients with advanced LC prior to anticancer therapy (87 non-small-cell LC and 61 small-cell LC) versus 100 well-matched controls, we measured HRG levels in association with clot permeability (Ks), clot turbidimetry (lag phase and maximum absorbance), and clot lysis time (CLT).
Results.
Compared to controls, LC patients had 45.9% lower HRG levels with no associations with demographics and comorbidities.
Decreased HRG, defined as the 90th percentile of control values (<52.7 μg/ml), was 16 times more common in subjects with than without LC (OR=16.4, 95% CI 9.2-23.5, p<0.01).
HRG<38 μg/ml discriminated stage IIIAB/limited disease from IV/extensive disease (ED) LC.
In LC patients, HRG correlated inversely with CLT (r=−0.41, p<0.001), but not with other fibrin variables.
Among stage IV/ED LC, HRG correlated significantly with Ks and lag phase (r=0.28 and r=0.33, respectively, both p<0.001).
LC patients with low Ks (10th percentile of control values) combined with prolonged CLT (90th percentile of control values) had reduced HRG levels compared to the remainder (p=0.003).
No such observations were noted in controls.
Conclusions.
Our study is the first to show that decreased HRG levels occur in advanced LC and are associated with the disease stage and hypofibrinolysis.
American Psychological Association (APA)
Winiarska, Aleksandra& Zareba, Lech& Krolczyk, Grzegorz& Czyzewicz, Grzegorz& Zabczyk, Michal& Undas, Anetta. 2019. Decreased Levels of Histidine-Rich Glycoprotein in Advanced Lung Cancer: Association with Prothrombotic Alterations. Disease Markers،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147839
Modern Language Association (MLA)
Winiarska, Aleksandra…[et al.]. Decreased Levels of Histidine-Rich Glycoprotein in Advanced Lung Cancer: Association with Prothrombotic Alterations. Disease Markers No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1147839
American Medical Association (AMA)
Winiarska, Aleksandra& Zareba, Lech& Krolczyk, Grzegorz& Czyzewicz, Grzegorz& Zabczyk, Michal& Undas, Anetta. Decreased Levels of Histidine-Rich Glycoprotein in Advanced Lung Cancer: Association with Prothrombotic Alterations. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147839
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147839