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Expression and Clinical Relevance of SOX9 in Gastric Cancer
Joint Authors
Barros, Rita
Almeida, Raquel
Mesquita, Patrícia
Freire, Ana F.
Lopes, Nair
Gomes, Rosa
Azevedo, Daniela
Pereira, Bruno
Cavadas, Bruno
Pópulo, Helena
Boaventura, Paula
Pereira, Luísa
David, L.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Gastric cancer is one of the most frequent tumours and the third leading cause of cancer-related death worldwide.
The investigation of new biomarkers that can predict patient outcome more accurately and allow better treatment and follow-up decisions is of crucial importance.
SOX9 (sex-determining region Y (SRY)-box 9) is a regulator of cell fate decisions in embryogenesis and adulthood.
Here, we sought to ascertain the relevance of SOX9 transcription factor as a prognostic marker in gastric cancer.
SOX9 expression was analyzed by immunohistochemistry in 333 gastric adenocarcinoma cases, and its association with clinicopathological and follow-up data was evaluated.
SOX9 nuclear expression was absent in 17% of gastric cancer cases and predicted worse disease-free survival (P=0.03).
SOX9 expression was associated with lower risk of relapse in Cox univariable analysis (HR=0.58; 95% CI=0.35-0.97; P=0.04).
The prognostic value of SOX9 was more pronounced in tumours with expansive growth (P=0.01) or with venous invasion (P=0.02).
Two validation cohorts from the Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG) confirmed that low SOX9 expression was significantly associated with poor patient outcome.
In conclusion, we have identified SOX9 as a biomarker of disease relapse in gastric cancer patients.
Further experiments are needed to elucidate its biological relevance at the cellular level.
American Psychological Association (APA)
Mesquita, Patrícia& Freire, Ana F.& Lopes, Nair& Gomes, Rosa& Azevedo, Daniela& Barros, Rita…[et al.]. 2019. Expression and Clinical Relevance of SOX9 in Gastric Cancer. Disease Markers،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1147849
Modern Language Association (MLA)
Mesquita, Patrícia…[et al.]. Expression and Clinical Relevance of SOX9 in Gastric Cancer. Disease Markers No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1147849
American Medical Association (AMA)
Mesquita, Patrícia& Freire, Ana F.& Lopes, Nair& Gomes, Rosa& Azevedo, Daniela& Barros, Rita…[et al.]. Expression and Clinical Relevance of SOX9 in Gastric Cancer. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1147849
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147849