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Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer
Joint Authors
Dillon, Patrick
Martin, Allison N.
Jones, David E.
Brenin, David R.
Lapides, David A.
Source
Case Reports in Oncological Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-09
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Paraneoplastic cerebellar degeneration (PCD) is a rare anti-Yo mediated paraneoplastic syndromes rarely that is infrequently associated with breast cancer.
We present a case of a 52-year-old female presenting with diplopia, gait instability, dysarthria, dysphagia, nystagmus, and, most notably, new onset paroxysmal episodes of uncontrollable crying concerning for pseudobulbar affect (PBA).
Serologic testing showed anti-Yo antibodies.
The patient was found to have stage IIIA breast cancer as the inciting cause of the paraneoplastic syndrome.
The patient was treated with neoadjuvant chemotherapy, modified radical mastectomy, adjuvant Herceptin, and pertuzumab.
She was given IVIG for paraneoplastic syndrome, antidepressants, and dextromethorphan-quinidine (Nuedexta), the first FDA-approved therapy for PBA.
With multimodality therapy, she demonstrated significant improvement in neurologic and mood symptoms associated with PCD and PBA.
American Psychological Association (APA)
Martin, Allison N.& Dillon, Patrick& Jones, David E.& Brenin, David R.& Lapides, David A.. 2017. Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer. Case Reports in Oncological Medicine،Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1147857
Modern Language Association (MLA)
Martin, Allison N.…[et al.]. Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer. Case Reports in Oncological Medicine No. 2017 (2017), pp.1-3.
https://search.emarefa.net/detail/BIM-1147857
American Medical Association (AMA)
Martin, Allison N.& Dillon, Patrick& Jones, David E.& Brenin, David R.& Lapides, David A.. Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer. Case Reports in Oncological Medicine. 2017. Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1147857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147857