Genetic Polymorphisms of IFNG and IFNGR1 with Latent Tuberculosis Infection
Joint Authors
He, Jian-Qing
Wu, Shouquan
Wang, Yu
Liu, Xiangmin
Zhang, Miaomiao
Wang, Minggui
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Previous studies indicated that single-nucleotide polymorphisms (SNPs) of interferon gamma (IFNG) and IFNG receptor 1 (IFNGR1) may be involved in the pathogenesis of pulmonary tuberculosis (PTB) in different populations.
In order to further explore the results in a Chinese Han population, this study was designed to investigate potential associations between the polymorphisms in IFNG and IFNGR1 and susceptibility to latent tuberculosis infection (LTBI) and/or PTB in a Chinese Han population.
A total of 209 PTB, 173 LTBI, and 183 healthy control subjects (HCS) were enrolled in our study.
Genotyping was conducted using an improved multiplex ligase detection reaction (iMLDR).
We performed a logistic regression including sex and age as covariates to test the effect of alleles/genotypes on LTBI and/or TB.
All six markers studied in IFNG and IFNGR1 conformed to the Hardy–Weinberg equilibrium (HWE).
The IFNG rs1861494 was significantly associated with LTBI in recessive model, and the CC+CT genotype decreased risk of LTBI by 50% (P=0.046, OR=0.50, 95%CI: 0.25-0.99).
The IFNGR1 rs2234711 was significantly associated with LTBI, and allele A increased the risk of LTBI by 55% (P=0.047, OR=1.55, 95%CI: 1.00-2.40).
In the present study, we found that IFNG and IFNGR1 polymorphisms were associated with LTBI.
American Psychological Association (APA)
Wu, Shouquan& Liu, Xiangmin& Wang, Yu& Zhang, Miaomiao& Wang, Minggui& He, Jian-Qing. 2019. Genetic Polymorphisms of IFNG and IFNGR1 with Latent Tuberculosis Infection. Disease Markers،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147863
Modern Language Association (MLA)
Wu, Shouquan…[et al.]. Genetic Polymorphisms of IFNG and IFNGR1 with Latent Tuberculosis Infection. Disease Markers No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1147863
American Medical Association (AMA)
Wu, Shouquan& Liu, Xiangmin& Wang, Yu& Zhang, Miaomiao& Wang, Minggui& He, Jian-Qing. Genetic Polymorphisms of IFNG and IFNGR1 with Latent Tuberculosis Infection. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147863
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147863