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Extensive Bone Marrow Necrosis: A Rare Presentation of Acute Lymphoblastic Leukaemia
Joint Authors
Shyamali, N. L. A.
Ranathunga, I.
Muthumala, N. R.
Kulathilake, H. W. C. K.
Weerasinghe, S.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-25
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Background.
Bone marrow necrosis (BMN) is a rare entity which presents with bone pain, fever, and peripheral cytopenia.
Acute lymphoblastic leukaemia (ALL) is characterized by malignant proliferation of immature lymphocytes, and patients usually present with fatigue and bleeding manifestations.
Presentation with BMN is an extremely rare finding and only few cases had been reported in the literature.
Case Presentation.
A 22-year-old male presented with nocturnal lower back ache, pleuritic central chest pain, and fever for two weeks.
He was extensively investigated for a cause.
His investigations revealed pancytopenia with severe neutropenia.
Initial bone marrow aspiration and biopsy did not provide a positive result due to extensive necrosis.
However, immunohistochemical analysis of few immature lymphoid cells on repeated BM biopsy showed evidence of acute lymphoblastic leukaemia.
Conclusions.
ALL usually presents with fatigue and bleeding manifestations.
Presentation with BMN is extremely rare.
The diagnosis was extremely challenging as this patient had only occasional atypical cells in the peripheral blood film and the repeat bone marrow (BM) biopsy showed extensive necrosis.
American Psychological Association (APA)
Ranathunga, I.& Muthumala, N. R.& Kulathilake, H. W. C. K.& Weerasinghe, S.& Shyamali, N. L. A.. 2020. Extensive Bone Marrow Necrosis: A Rare Presentation of Acute Lymphoblastic Leukaemia. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-3.
https://search.emarefa.net/detail/BIM-1147873
Modern Language Association (MLA)
Ranathunga, I.…[et al.]. Extensive Bone Marrow Necrosis: A Rare Presentation of Acute Lymphoblastic Leukaemia. Case Reports in Hematology No. 2020 (2020), pp.1-3.
https://search.emarefa.net/detail/BIM-1147873
American Medical Association (AMA)
Ranathunga, I.& Muthumala, N. R.& Kulathilake, H. W. C. K.& Weerasinghe, S.& Shyamali, N. L. A.. Extensive Bone Marrow Necrosis: A Rare Presentation of Acute Lymphoblastic Leukaemia. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-3.
https://search.emarefa.net/detail/BIM-1147873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147873