Intestinal Alkaline Phosphatase Deficiency Is Associated with Ischemic Heart Disease
Joint Authors
Malo, Jagannath
Alam, Md. Jahangir
Shahnaz, Munjareen
Kaliannan, Kanakaraju
Chandra, Gopal
Aziz, Tarek
Sarker, Tapas
Bala, Mihir
Paul, Ratna
Saha, Chandan K.
Karmakar, Pradip K.
Malo, Madhu S.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
We have previously shown that the deficiency of the gut enzyme intestinal alkaline phosphatase (IAP) is associated with type 2 diabetes mellitus (T2DM) in humans, and mice deficient in IAP develop the metabolic syndrome, a precipitant of T2DM and ischemic heart disease (IHD).
We hypothesized that IAP deficiency might also be associated with IHD in humans.
We aimed to determine the correlation between the IAP level and IHD in humans.
Methods and Results.
The IHD patients were recruited from the National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh, and the control healthy participants were recruited from a suburban community of Dhaka.
We determined the IAP level in the stools of 292 IHD patients (187 males, 105 females) and 331 healthy control people (84 males, 247 females).
We found that compared to controls, IHD patients have approx.
30% less IAP (mean±SEM: 63.7±3.5 vs.
44.9±2.1 U/g stool, respectively; p<0.000001), which indicates that IAP deficiency is associated with IHD, and a high level of IAP is probably protective against IHD in humans.
The adjusted generalized linear model (GLM) of regression analysis predicted a strong association of IAP with IHD (p=0.0035).
Multiple logistic regression analysis showed an independent inverse relationship between the IAP level and the IHD status (odds ratio, OR=0.993 with 95% CI 0.987-0.998; p<0.01).
Conclusions.
IAP deficiency is associated with IHD, and a high level of IAP might be protective against IHD.
American Psychological Association (APA)
Malo, Jagannath& Alam, Md. Jahangir& Shahnaz, Munjareen& Kaliannan, Kanakaraju& Chandra, Gopal& Aziz, Tarek…[et al.]. 2019. Intestinal Alkaline Phosphatase Deficiency Is Associated with Ischemic Heart Disease. Disease Markers،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1147876
Modern Language Association (MLA)
Malo, Jagannath…[et al.]. Intestinal Alkaline Phosphatase Deficiency Is Associated with Ischemic Heart Disease. Disease Markers No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1147876
American Medical Association (AMA)
Malo, Jagannath& Alam, Md. Jahangir& Shahnaz, Munjareen& Kaliannan, Kanakaraju& Chandra, Gopal& Aziz, Tarek…[et al.]. Intestinal Alkaline Phosphatase Deficiency Is Associated with Ischemic Heart Disease. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1147876
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147876