Combination of Dabrafenib and Trametinib for the Treatment of Relapsed and Refractory Multiple Myeloma Harboring BRAF V600E Mutation
Joint Authors
Čepulytė, Rūta
Žučenka, Andrius
Pečeliūnas, Valdas
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Multiple myeloma (MM) is an incurable plasma cell neoplasia characterized by relapsed and/or refractory (R/R) disease course, which poses a major therapeutic challenge.
New therapies, including BRAF V600E mutation targeting, may become a new treatment option for R/R MM.
In combination with mitogen-activated protein kinase inhibitors (MEKi), BRAF inhibitors (BRAFi) could provide better tailored clinical management, although experience in this field is lacking.
To this date, there is only one case describing R/R MM treatment with BRAFi vemurafenib and MEKi cobimetinib.
This is the first case presenting a R/R MM patient treated with BRAFi dabrafenib and MEKi trametinib.
American Psychological Association (APA)
Čepulytė, Rūta& Žučenka, Andrius& Pečeliūnas, Valdas. 2020. Combination of Dabrafenib and Trametinib for the Treatment of Relapsed and Refractory Multiple Myeloma Harboring BRAF V600E Mutation. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1147890
Modern Language Association (MLA)
Čepulytė, Rūta…[et al.]. Combination of Dabrafenib and Trametinib for the Treatment of Relapsed and Refractory Multiple Myeloma Harboring BRAF V600E Mutation. Case Reports in Hematology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1147890
American Medical Association (AMA)
Čepulytė, Rūta& Žučenka, Andrius& Pečeliūnas, Valdas. Combination of Dabrafenib and Trametinib for the Treatment of Relapsed and Refractory Multiple Myeloma Harboring BRAF V600E Mutation. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1147890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147890