MicroRNA Signatures in Malignant Pleural Mesothelioma Effusions
Joint Authors
Creaney, Jenette
Musk, Arthur William
Birnie, Kimberly A.
Prêle, Cecilia M.
de Klerk, Nicholas
Lee, Y. C. Gary
Fitzgerald, Deirdre
Allcock, Richard J. N.
Thompson, Philip J.
Badrian, Bahareh
Mutsaers, Steven E.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Malignant pleural mesothelioma (MPM) is an incurable cancer of the pleura that can be difficult to diagnose.
Biomarkers for an easier and/or earlier diagnosis are needed.
Approximately 90% of MPM patients develop a pleural effusion (PE).
PEs are ideal sources of biomarkers as the fluid would almost always require drainage for diagnostic and/or therapeutic reasons.
However, differentiating MPM PE from PE caused by other diseases can be challenging.
MicroRNAs are popular biomarkers given their stable expression in tissue and fluid.
MicroRNAs have been analysed in PE cytology samples for the diagnosis of MPM but have not been measured in frozen/fresh PE.
We hypothesise that microRNAs expressed in PE are biomarkers for MPM.
TaqMan OpenArray was used to analyse over 700 microRNAs in PE cells and supernatants from 26 MPMs and 21 other PE-causing diseases.
In PE cells, combining miR-143, miR-210, and miR-200c could differentiate MPM with an area under the curve (AUC) of 0.92.
The three-microRNA signature could also discriminate MPM from a further 40 adenocarcinomas with an AUC of 0.9887.
These results suggest that the expression of miR-143, miR-210, and miR-200c in PE cells might provide a signature for diagnosing MPM.
American Psychological Association (APA)
Birnie, Kimberly A.& Prêle, Cecilia M.& Musk, Arthur William& de Klerk, Nicholas& Lee, Y. C. Gary& Fitzgerald, Deirdre…[et al.]. 2019. MicroRNA Signatures in Malignant Pleural Mesothelioma Effusions. Disease Markers،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147893
Modern Language Association (MLA)
Birnie, Kimberly A.…[et al.]. MicroRNA Signatures in Malignant Pleural Mesothelioma Effusions. Disease Markers No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1147893
American Medical Association (AMA)
Birnie, Kimberly A.& Prêle, Cecilia M.& Musk, Arthur William& de Klerk, Nicholas& Lee, Y. C. Gary& Fitzgerald, Deirdre…[et al.]. MicroRNA Signatures in Malignant Pleural Mesothelioma Effusions. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147893