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Myelodysplasia and Mast Cell Leukemia with t(9;22)
Joint Authors
Velagaleti, Gopalrao V. N.
Lago, Kathryn J.
Shupe, Matthew P.
Hannah, William N.
Mendiola, Christina
Haney, Brian R.
Ortega, Veronica
Source
Case Reports in Oncological Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Mast cell leukemia (MCL) is a rare variant of systemic mastocytosis.
Most cases of mast cell leukemia do not have cytogenics performed.
Furthermore, there is no consistent chromosomal abnormality identified in MCL.
This is the first reported case of MCL with a (9;22) translocation.
Case Report.
An 80-year-old female presented with pancytopenia and was diagnosed with MDS.
Over time, she required hospitalizations for platelet transfusions with increased frequency.
She developed fatigue and weakness along with gastrointestinal symptoms.
On exam, she had diffuse abdominal tenderness and a maculopapular rash.
Her lab results revealed a new basophilia.
A bone marrow biopsy showed 100% cellularity with many aggregates of mast cells.
Chromosomal analysis showed t(9;22) with confirmed BCR/ABL1 fusion by fluorescence in situ hybridization (FISH).
Discussion.
MCL has a poor prognosis due to the aggressive nature of the disease and ineffective therapies.
Translocation (9;22) is known to be associated with MDS transformations to acute leukemia; however, this translocation has never been reported in MCL.
Further research on the relationship between t(9;22) and MCL could lead to development of improved therapeutic options.
American Psychological Association (APA)
Lago, Kathryn J.& Shupe, Matthew P.& Hannah, William N.& Velagaleti, Gopalrao V. N.& Mendiola, Christina& Ortega, Veronica…[et al.]. 2017. Myelodysplasia and Mast Cell Leukemia with t(9;22). Case Reports in Oncological Medicine،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1147896
Modern Language Association (MLA)
Lago, Kathryn J.…[et al.]. Myelodysplasia and Mast Cell Leukemia with t(9;22). Case Reports in Oncological Medicine No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1147896
American Medical Association (AMA)
Lago, Kathryn J.& Shupe, Matthew P.& Hannah, William N.& Velagaleti, Gopalrao V. N.& Mendiola, Christina& Ortega, Veronica…[et al.]. Myelodysplasia and Mast Cell Leukemia with t(9;22). Case Reports in Oncological Medicine. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1147896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147896