Myelodysplastic Syndrome with Transfusion Dependence Treated with Venetoclax
Joint Authors
Jehangir, Waqas
Karabachev, Alexander
Jahangir, Taimoor
Umyarova, Elvira
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-12
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Myelodysplastic syndromes are characterized by ineffective hematopoiesis in one or more lineages of the bone marrow.
They are a group of heterogeneous clonal stem cell malignancies with a high risk to progress to acute myeloid leukemia.
Currently, there are no curative FDA-approved medications for myelodysplastic syndromes.
Hematopoietic cell transplantation is potentially the only curative option; however, treatment is often unavailable due to age and comorbidities.
Hypomethylating agents, azacitidine and decitabine, and the immunomodulatory agent, lenalidomide, are the only FDA approved medications for the treatment of MDS, all of which are noncurative.
Venetoclax, an inhibitor of the antiapoptotic protein BCL-2 used to treat chronic lymphocytic leukemia, is currently being evaluated in clinical trials as a monotherapy in high-risk myelodysplastic syndromes/acute myeloid leukemia.
We present a patient with transfusion-dependent myelodysplastic syndromes refractory to the current standard of care treatment not a candidate for hematopoietic cell transplantation who responded well to monotherapy treatment with venetoclax and has since remained transfusion-independent.
American Psychological Association (APA)
Jehangir, Waqas& Karabachev, Alexander& Jahangir, Taimoor& Umyarova, Elvira. 2020. Myelodysplastic Syndrome with Transfusion Dependence Treated with Venetoclax. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147902
Modern Language Association (MLA)
Jehangir, Waqas…[et al.]. Myelodysplastic Syndrome with Transfusion Dependence Treated with Venetoclax. Case Reports in Hematology No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1147902
American Medical Association (AMA)
Jehangir, Waqas& Karabachev, Alexander& Jahangir, Taimoor& Umyarova, Elvira. Myelodysplastic Syndrome with Transfusion Dependence Treated with Venetoclax. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147902
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147902