Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head
Joint Authors
Jin, Hongting
Zhu, Zhongxin
Tong, Peijian
Du, Wenxi
Yu, Huan
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
A growing number of studies have suggested that circular RNAs (circRNAs) serve as potential diagnostic biomarkers in many diseases.
However, the role of circRNAs in steroid-induced osteonecrosis of the femoral head (SONFH) has not been reported.
Methods.
Secondary sequencing was performed to profile circRNA expression in peripheral blood samples from three SONFH patients and three healthy individuals.
We confirmed our preliminary findings by qRT-PCR.
Bioinformatics analysis was conducted to predict their functions.
Results.
The result showed 345 dysregulated circRNAs.
qRT-PCR of eight selected circRNAs preliminarily confirmed the results, which were consistent with RNA sequencing.
Bioinformatics analyses were performed to predict the functions of circRNAs to target the genes of miRNAs and the networks of circRNA-miRNA-mRNA interactions.
Conclusions.
This study provides a new and fundamental circRNA profile of SONFH and a theoretical basis for further studies on the functions of circRNAs in SONFH.
American Psychological Association (APA)
Zhu, Zhongxin& Du, Wenxi& Yu, Huan& Jin, Hongting& Tong, Peijian. 2019. Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head. Disease Markers،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1147909
Modern Language Association (MLA)
Zhu, Zhongxin…[et al.]. Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head. Disease Markers No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1147909
American Medical Association (AMA)
Zhu, Zhongxin& Du, Wenxi& Yu, Huan& Jin, Hongting& Tong, Peijian. Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1147909
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147909