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Successful Kidney Transplantation in a Recipient Coinfected with Hepatitis C Genotype 2 and HIV from a Donor Infected with Hepatitis C Genotype 1 in the Direct-Acting Antiviral Era
Joint Authors
Morrissey, P. E.
Farmakiotis, Dimitrios
Weiss, Zoe
Brotherton, Amy L.
Gohh, Reginald
Vieira, Kendra
Taylor, Lynn E.
Garland, Joseph M.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Despite significant advances in transplantation of HIV-infected individuals, little is known about HIV coinfected patients with hepatitis C virus (HCV) genotypes other than genotype 1, especially when receiving HCV-infected organs with a different genotype.
We describe the first case of kidney transplantation in a man coinfected with hepatitis C and HIV in our state.
To our knowledge, this is also the first report of an HIV/HCV/HBV tri-infected patient with non-1 (2a) HCV genotype who received an HCV-infected kidney graft with the discordant genotype (1a), to which he converted after transplant.
Our case study highlights the following: (1) transplant centers need to monitor wait times for an HCV-infected organ and regularly assess the risk of delaying HCV antiviral treatment for HCV-infected transplant candidates in anticipation of the transplant from an HCV-infected donor; (2) closer monitoring of tacrolimus levels during the early phases of anti-HCV protease inhibitor introduction and discontinuation may be indicated; (3) donor genotype transmission can occur; (4) HIV/HCV coinfected transplant candidates require a holistic approach with emphasis on the cardiovascular risk profile and low threshold for cardiac catheterization as part of their pretransplant evaluation.
American Psychological Association (APA)
Farmakiotis, Dimitrios& Weiss, Zoe& Brotherton, Amy L.& Morrissey, P. E.& Gohh, Reginald& Vieira, Kendra…[et al.]. 2020. Successful Kidney Transplantation in a Recipient Coinfected with Hepatitis C Genotype 2 and HIV from a Donor Infected with Hepatitis C Genotype 1 in the Direct-Acting Antiviral Era. Case Reports in Hepatology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1147931
Modern Language Association (MLA)
Farmakiotis, Dimitrios…[et al.]. Successful Kidney Transplantation in a Recipient Coinfected with Hepatitis C Genotype 2 and HIV from a Donor Infected with Hepatitis C Genotype 1 in the Direct-Acting Antiviral Era. Case Reports in Hepatology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1147931
American Medical Association (AMA)
Farmakiotis, Dimitrios& Weiss, Zoe& Brotherton, Amy L.& Morrissey, P. E.& Gohh, Reginald& Vieira, Kendra…[et al.]. Successful Kidney Transplantation in a Recipient Coinfected with Hepatitis C Genotype 2 and HIV from a Donor Infected with Hepatitis C Genotype 1 in the Direct-Acting Antiviral Era. Case Reports in Hepatology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1147931
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147931