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The Role of Exosomes in Bone Remodeling: Implications for Bone Physiology and Disease
Joint Authors
Theocharis, Stamatios
Masaoutis, Christos
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Bone remodeling represents a physiological phenomenon of continuous bone tissue renewal that requires fine orchestration of multiple cell types, which is critical for the understanding of bone disease but not yet clarified in precise detail.
Exosomes, which are cell-secreted nanovesicles drawing increasing attention for their broad biosignaling functions, can shed new light on how multiple heterogeneous cells communicate for the purpose of bone remodeling.
In the healthy bone, exosomes transmit signals favoring both bone synthesis and resorption, regulating the differentiation, recruitment, and activity of most cell types involved in bone remodeling and even assuming an active role in extracellular matrix mineralization.
Additionally, in the ailing bone, they actively participate in pathogenic processes constituting also potential therapeutic agents and drug vectors.
The present review summarizes the current knowledge on bone exosomes and bone remodeling in health and disease.
American Psychological Association (APA)
Masaoutis, Christos& Theocharis, Stamatios. 2019. The Role of Exosomes in Bone Remodeling: Implications for Bone Physiology and Disease. Disease Markers،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1147997
Modern Language Association (MLA)
Masaoutis, Christos& Theocharis, Stamatios. The Role of Exosomes in Bone Remodeling: Implications for Bone Physiology and Disease. Disease Markers No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1147997
American Medical Association (AMA)
Masaoutis, Christos& Theocharis, Stamatios. The Role of Exosomes in Bone Remodeling: Implications for Bone Physiology and Disease. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1147997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147997