Corin Is Downregulated in Renal IschemiaReperfusion Injury and Is Associated with Delayed Graft Function after Kidney Transplantation
Joint Authors
Tian, Ye
Hu, Xinyi
Su, Ming
Qiu, Wei
Lin, Jun
Zhang, Lei
Sun, Wen
Zhang, Jian
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Renal ischemia/reperfusion (IR) injury is one of the most important risk factors for the occurrence of delayed graft function (DGF) after kidney transplantation; however, its mechanism remains not fully understood.
In the present study, we screened differentially expressed genes in a murine model of renal IR injury by using high-throughput assays.
We identified Corin as one of the most significantly downregulated genes among 2218 differentially expressed genes (≥2-fold, P<0.05).
By using a real-time qPCR assay, we observed that the expression of renal Corin in IR-injured mice was reduced to 11.5% of the sham-operated mice and that the protein level of renal Corin in IR-injured mice was also downregulated.
Interestingly, renal IR injury in mice induced the downregulation of Corin in heart tissues, suggesting that the overall synthesis of Corin may be suppressed.
We recruited 11 recipients complicated with DGF and 16 without DGF, and plasma Corin concentrations were determined by ELISA.
We observed that the plasma Corin levels were indeed reduced in recipients complicated with DGF (0.98 vs.
1.95 ng/ml, P<0.05).
These findings demonstrate that Corin may be a potential biomarker of DGF after kidney transplantation and may participate in the regulation of renal IR injury.
American Psychological Association (APA)
Hu, Xinyi& Su, Ming& Lin, Jun& Zhang, Lei& Sun, Wen& Zhang, Jian…[et al.]. 2019. Corin Is Downregulated in Renal IschemiaReperfusion Injury and Is Associated with Delayed Graft Function after Kidney Transplantation. Disease Markers،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1148005
Modern Language Association (MLA)
Hu, Xinyi…[et al.]. Corin Is Downregulated in Renal IschemiaReperfusion Injury and Is Associated with Delayed Graft Function after Kidney Transplantation. Disease Markers No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1148005
American Medical Association (AMA)
Hu, Xinyi& Su, Ming& Lin, Jun& Zhang, Lei& Sun, Wen& Zhang, Jian…[et al.]. Corin Is Downregulated in Renal IschemiaReperfusion Injury and Is Associated with Delayed Graft Function after Kidney Transplantation. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1148005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148005