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Association between the -844 G>A, HindIII C>G, and 4G5G PAI-1 Polymorphisms and Susceptibility to Multiple Sclerosis in Western Mexican Population
Joint Authors
Padilla-Gutiérrez, Jorge Ramón
Valle, Yeminia
Muñoz-Valle, Jose F.
Valdés-Alvarado, Emmanuel
Huerta, Miguel
Trujillo, Xochitl
Mireles-Ramírez, Mario Alberto
Macías-Islas, Miguel Angel
Luz Margarita, Baltazar-Rodríguez
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Multiple sclerosis is an inflammatory disease, where fibrin deposition and the impairment in its degradation have been shown to play an important role in the demyelination process.
Tissue plasminogen activator (tPA) is a serine protease that enhances the conversion of plasminogen into its active form plasmin, the principal tPA inhibitor is the PAI-1.
Several PAI-1 polymorphisms impact its gene expression and protein activity.
Furthermore, the aim of this study was to investigate the association between the - 844 G>A, HindIII C>G, and 4G/5G PAI-1 polymorphisms and susceptibility to MS.
Material and Methods.
The study group included 400 Mexican mestizo subjects: 200 unrelated patients and 200 unrelated individuals identified as control subjects.
The analysis of PAI-1 polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism.
Results.
A significant association was found between the CG genotype of the HindIII C>G PAI-1 polymorphism and susceptibility to MS (OR=1.58, p=0.03); moreover, the frequency of 5G allele and 5G/5G genotype of the 4G/5G PAI-1 polymorphism was statistically significant (OR=1.36 and p=0.04 and OR=2.43 and p=0.02, respectively).
With respect to the relation between the scores of progression (EDSS) and severity (MSSS), no association was found between EDSS and genotypes of the PAI-1 polymorphisms analyzed.
Regarding MSSS, male that carries genotype GA of the -844 G>A and genotype 4G/5G of the 4G/5G PAI-1 polymorphisms showed a significant association with an increase of media of MSSS in comparison with females (p=0.01 in both cases).
American Psychological Association (APA)
Valdés-Alvarado, Emmanuel& Huerta, Miguel& Trujillo, Xochitl& Valle, Yeminia& Padilla-Gutiérrez, Jorge Ramón& Mireles-Ramírez, Mario Alberto…[et al.]. 2019. Association between the -844 G>A, HindIII C>G, and 4G5G PAI-1 Polymorphisms and Susceptibility to Multiple Sclerosis in Western Mexican Population. Disease Markers،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1148043
Modern Language Association (MLA)
Valdés-Alvarado, Emmanuel…[et al.]. Association between the -844 G>A, HindIII C>G, and 4G5G PAI-1 Polymorphisms and Susceptibility to Multiple Sclerosis in Western Mexican Population. Disease Markers No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1148043
American Medical Association (AMA)
Valdés-Alvarado, Emmanuel& Huerta, Miguel& Trujillo, Xochitl& Valle, Yeminia& Padilla-Gutiérrez, Jorge Ramón& Mireles-Ramírez, Mario Alberto…[et al.]. Association between the -844 G>A, HindIII C>G, and 4G5G PAI-1 Polymorphisms and Susceptibility to Multiple Sclerosis in Western Mexican Population. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1148043
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148043