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The Clinical Effect of Oral Vitamin D2 Supplementation on Psoriasis: A Double-Blind, Randomized, Placebo-Controlled Study
Joint Authors
Disphanurat, Wareeporn
Viarasilpa, Wongsiya
Chakkavittumrong, Panlop
Pongcharoen, Padcha
Source
Dermatology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
There are limited randomized controlled trials of oral vitamin D supplementation in psoriasis, especially in Asia, and the results are inconclusive.
Objective.
To investigate the clinical effect of oral vitamin D supplementation on psoriasis.
Methods.
Patients with psoriasis were randomized to receive vitamin D2 60,000 IU or similar-looking placebo pills once every 2 weeks for 6 months.
The primary outcome was improvement of the Psoriasis Area and Severity Index (PASI) score at 3 and 6 months after treatment.
Serum levels of 25(OH)D, calcium, phosphate, parathyroid hormone, and C-reactive protein and adverse events were monitored.
The chi-square test, Fisher’s exact test, Student’s t-test, and Spearman’s correlation analysis were used in statistical analysis.
Results.
Of 50 subjects screened, 45 were eligible and randomized to the oral vitamin D2 group (n=23) or placebo group (n=22).
At enrollment, the mean PASI score was 4.45, and 26.7% of patients had vitamin D deficiency.
At 3 months, the oral vitamin D2 group had significantly higher PASI improvement than the placebo group (mean PASI improvement: 1.43 versus [vs.] -0.33, p-value=0.034; mean %PASI improvement: 34.21% vs.
-1.85%, p-value=0.039).
The mean serum 25(OH)D level was significantly higher in the oral vitamin D group than in the placebo group (27.4 vs.
22.4 ng/mL, p-value=0.029).
Serum 25(OH)D concentrations were significantly inversely correlated with PASI scores at the 6-month follow-up.
No major adverse event was observed overall.
Conclusion.
Oral vitamin D2 supplementation in patients with psoriasis increased the serum vitamin D level and significantly improved the treatment outcome without increasing adverse events.
Trial Registration.
This trial is registered with Thai Clinical Trials Registry TCTR20180613001.
American Psychological Association (APA)
Disphanurat, Wareeporn& Viarasilpa, Wongsiya& Chakkavittumrong, Panlop& Pongcharoen, Padcha. 2019. The Clinical Effect of Oral Vitamin D2 Supplementation on Psoriasis: A Double-Blind, Randomized, Placebo-Controlled Study. Dermatology Research and Practice،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1148111
Modern Language Association (MLA)
Disphanurat, Wareeporn…[et al.]. The Clinical Effect of Oral Vitamin D2 Supplementation on Psoriasis: A Double-Blind, Randomized, Placebo-Controlled Study. Dermatology Research and Practice No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1148111
American Medical Association (AMA)
Disphanurat, Wareeporn& Viarasilpa, Wongsiya& Chakkavittumrong, Panlop& Pongcharoen, Padcha. The Clinical Effect of Oral Vitamin D2 Supplementation on Psoriasis: A Double-Blind, Randomized, Placebo-Controlled Study. Dermatology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1148111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148111