Two Functional TP53 Genetic Variants and Predisposition to Keloid Scarring in Caucasians
Joint Authors
Gorący, Iwona
Dmytrzak, Andrzej
Lewandowska, Klaudyna
Kaczmarczyk, Mariusz
Loniewska, Beata
Bińczak-Kuleta, Agnieszka
Ciechanowicz, Andrzej
Source
Dermatology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-13
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Keloid is defined as a benign proliferative scar that grows beyond the confines of the original insult to the skin, invading into adjacent normal tissue.
The pathogenesis of keloid is complex, and many evidences suggest the influence of genetic factors, among them the polymorphisms of the TP53 gene encoding tumor protein p53.
Objective.
To investigate the association of rs1042522 (c.215G>C, p.Arg72Pro) and rs17878362 (16-bp insertion/duplication in intron 3) variants, two most frequently analyzed TP53 functional polymorphisms and the risk of keloid in Polish patients.
Materials and Methods.
The rs1042522 and rs17878362 polymorphisms were identified by sequencing genomic DNA extracted from peripheral blood leukocytes of 86 keloid patients and from cordial blood leukocytes of 100 newborn infants consisting control group.
Results.
The rs1042522 and rs17878362 TP53 genotype distributions both in keloid patients and in the control group conformed to the expected Hardy–Weinberg equilibrium.
No significant differences in the distribution of rs1042522 and rs17878362 TP53 alleles or genotypes have been found between keloid patients and newborn controls.
There is tight, but not complete, linkage disequilibrium between rs1042522 and rs17878362 TP53 polymorphisms (D′ = 0.667, r = 0.448, and p=0).
No significant differences in the distribution of rs1042522 and rs17878362 TP53 haplotypes or diplotypes have been found between keloid patients and newborn controls.
Conclusions.
Our results suggest the lack of association of rs1042522 and rs17878362 TP53 polymorphisms and their haplotypes or diplotypes with the susceptibility to keloid scarring in Polish patients.
American Psychological Association (APA)
Dmytrzak, Andrzej& Bińczak-Kuleta, Agnieszka& Loniewska, Beata& Lewandowska, Klaudyna& Gorący, Iwona& Kaczmarczyk, Mariusz…[et al.]. 2019. Two Functional TP53 Genetic Variants and Predisposition to Keloid Scarring in Caucasians. Dermatology Research and Practice،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1148115
Modern Language Association (MLA)
Dmytrzak, Andrzej…[et al.]. Two Functional TP53 Genetic Variants and Predisposition to Keloid Scarring in Caucasians. Dermatology Research and Practice No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1148115
American Medical Association (AMA)
Dmytrzak, Andrzej& Bińczak-Kuleta, Agnieszka& Loniewska, Beata& Lewandowska, Klaudyna& Gorący, Iwona& Kaczmarczyk, Mariusz…[et al.]. Two Functional TP53 Genetic Variants and Predisposition to Keloid Scarring in Caucasians. Dermatology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1148115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148115