Radiotherapy for Melanoma: More than DNA Damage
Joint Authors
Rogers, Susanne J.
Puric, Emsad
Eberle, Brigitte
Datta, Niloy R.
Bodis, Stephan
Source
Dermatology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Despite its reputation as a radioresistant tumour, there is evidence to support a role for radiotherapy in patients with melanoma and we summarise current clinical practice.
Melanoma is a highly immunogenic tumour and in this era of immunotherapy, there is renewed interest in the potential of irradiation, not only as an adjuvant and palliative treatment, but also as an immune stimulant.
It has long been known that radiation causes not only DNA strand breaks, apoptosis, and necrosis, but also immunogenic modulation and cell death through the induction of dendritic cells, cell adhesion molecules, death receptors, and tumour-associated antigens, effectively transforming the tumour into an individualised vaccine.
This immune response can be enhanced by the application of clinical hyperthermia as evidenced by randomised trial data in patients with melanoma.
The large fraction sizes used in cranial radiosurgery and stereotactic body radiotherapy are more immunogenic than conventional fractionation, which provides additional radiobiological justification for these techniques in this disease entity.
Given the immune priming effect of radiotherapy, there is a strong but complex biological rationale and an increasing body of evidence for synergy in combination with immune checkpoint inhibitors, which are now first-line therapy in patients with recurrent or metastatic melanoma.
There is great potential to increase local control and abscopal effects by combining radiotherapy with both immunotherapy and hyperthermia, and a combination of all three modalities is suggested as the next important trial in this refractory disease.
American Psychological Association (APA)
Rogers, Susanne J.& Puric, Emsad& Eberle, Brigitte& Datta, Niloy R.& Bodis, Stephan. 2019. Radiotherapy for Melanoma: More than DNA Damage. Dermatology Research and Practice،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1148141
Modern Language Association (MLA)
Rogers, Susanne J.…[et al.]. Radiotherapy for Melanoma: More than DNA Damage. Dermatology Research and Practice No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1148141
American Medical Association (AMA)
Rogers, Susanne J.& Puric, Emsad& Eberle, Brigitte& Datta, Niloy R.& Bodis, Stephan. Radiotherapy for Melanoma: More than DNA Damage. Dermatology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1148141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148141