Atypical Lipomatous TumorWell-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature
Joint Authors
Sairyo, Koichi
Toki, Shunichi
Nishisho, Toshihiko
Miyagi, Ryo
Takata, Shinjiro
Shimatani, Yoshimitsu
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-29
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLS) is an intermediate or locally aggressive form of adipocytic soft tissue sarcoma.
Muscular dystrophy (MD) is characterized by progressive muscle atrophy and its replacement by adipose and fibrous tissue.
Recently, some authors have reported that MD genes are related to neoplastic formation, but there have been no detailed clinical reports of ALT associated with MD.
Case Presentation.
A 73-year-old woman with a diagnosis of limb-girdle MD visited our department for recurrence of a huge tumor in her left thigh.
She had undergone resection of a lipoma at the same site more than 20 years earlier.
Imaging studies revealed a lipomatous tumor in her left thigh.
We performed marginal resection including the adjacent muscles.
Histological diagnosis was atypical lipomatous tumor.
The postoperative course was uneventful, with no recurrence at 36 months of follow-up.
Conclusion.
We encountered a huge atypical tumor in a patient with MD.
This is the first detailed report to describe an association between ALT and MD.
We hypothesize that degenerative changes occurring in adipose tissue during muscle atrophy can cause lipomatous neoplasms and moreover that the mutation of MD-related genes may lead to the proliferation of tumor cells or to malignancy.
American Psychological Association (APA)
Miyagi, Ryo& Nishisho, Toshihiko& Takata, Shinjiro& Shimatani, Yoshimitsu& Toki, Shunichi& Sairyo, Koichi. 2017. Atypical Lipomatous TumorWell-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature. Case Reports in Orthopedics،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1148258
Modern Language Association (MLA)
Miyagi, Ryo…[et al.]. Atypical Lipomatous TumorWell-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature. Case Reports in Orthopedics No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1148258
American Medical Association (AMA)
Miyagi, Ryo& Nishisho, Toshihiko& Takata, Shinjiro& Shimatani, Yoshimitsu& Toki, Shunichi& Sairyo, Koichi. Atypical Lipomatous TumorWell-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature. Case Reports in Orthopedics. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1148258
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148258