Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases

Abstract EN

In Tenosynovial Giant Cell Tumours (TGCT), previously named Pigmented Villonodular Synovitis (PVNS), a distinction is made between a single nodule (localized-type) and multiple nodules (diffuse-type).

Diffuse-type is considered locally aggressive.

Onset and extermination of this orphan disease remain unclear.

Surgical resection is the most commonly performed treatment.

Unfortunately, recurrences often occur (up to 92%), necessitating reoperations and adjuvant treatments.

Once all treatments fail or if severe complications occur, limb amputation may become unavoidable.

We describe four cases of above-knee amputation after TGCT diagnosis.