Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature
Joint Authors
León, Jorge Esquiche
Kaminagakura, Estela
Ribeiro El-Achkar, Vivian Narana
Duarte, Andressa
Pinto Saggioro, Fabiano
De Mello Filho, Francisco Veríssimo
Ribeiro-Silva, Alfredo
Source
Case Reports in Otolaryngology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
The malignant transformation of laryngeal papillomatosis (LP) into squamous cell carcinoma (SCC) can occur in up to 4% of LP cases.
The low-risk HPV types 6 and 11 are those that are most commonly related to LP; however, high-risk HPV types may be present.
The present study reviews the literature on cases of malignant transformation of LP in adults and reports a clinical case.
Case Report.
A 47-year-old male patient exhibiting hoarseness for 4 months presented an exophytic lesion in the right palatine tonsil and a digitiform-like lesion in the right vocal fold.
The biopsy revealed a well-differentiated SCC in the vocal cord, which showed a transition zone with a squamous papillomatous lesion.
By using the chromogenic in situ hybridization (CISH) test, both lesions showed a positive result for high-risk HPV types 16 and 18 and negative for low-risk HPV types 6 and 11.
The final diagnosis was SCC arising from LP.
The patient underwent surgical treatment.
After 36 months of follow-up, no signs of recurrence were observed.
Results.
The literature review revealed 25 cases of malignant transformation into SCC of LP with adult onset.
Of these, only 9 cases were assessed by CISH and/or PCR for HPV identification, of which 7 were positive.
The current study focuses on the eighth case, suggesting the involvement of the high-risk HPV types in its pathogenesis.
Conclusions.
LP is considered a benign lesion with the potential for malignant transformation, which reinforces the need for its early diagnosis and the constant monitoring of patients with LP.
American Psychological Association (APA)
Ribeiro El-Achkar, Vivian Narana& Duarte, Andressa& Pinto Saggioro, Fabiano& De Mello Filho, Francisco Veríssimo& León, Jorge Esquiche& Ribeiro-Silva, Alfredo…[et al.]. 2018. Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature. Case Reports in Otolaryngology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1148426
Modern Language Association (MLA)
Ribeiro El-Achkar, Vivian Narana…[et al.]. Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature. Case Reports in Otolaryngology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1148426
American Medical Association (AMA)
Ribeiro El-Achkar, Vivian Narana& Duarte, Andressa& Pinto Saggioro, Fabiano& De Mello Filho, Francisco Veríssimo& León, Jorge Esquiche& Ribeiro-Silva, Alfredo…[et al.]. Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature. Case Reports in Otolaryngology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1148426
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148426