Methotrexate-Associated Lymphoproliferative Disorder Developed Ectopically in the Maxillary Gingiva and Bilateral Lungs
Joint Authors
Obata, Kyoichi
Kishimoto, Koji
Sasaki, Akira
Okui, Tatsuo
Ibaragi, Soichiro
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A 58-year-old Japanese woman complained of a painful right maxillary premolar gingiva and ulcer.
The patient had RA and had been treated with several immunosuppressive drugs such as methotrexate.
Head and neck CT indicated no obvious bone destruction with maxillary.
However, chest CT indicated the presence of nodular mass of the bilateral lungs.
FDG-PET/CT indicated the presence of increased uptake in both lesions.
On immunohistochemistry, atypical large-sized lymphocytes were positive for CD20 and EBER-ISH and negative for CD3, CD5, and CD10; the Ki-67 labeling index was high, the histopathological diagnosis was EBV-positive DLBCL, and the clinical diagnosis was MTX-LPD.
The patient’s treatment with MTX was then discontinued; we removed the alveolar bone which necrosed after 5 weeks.
The lesion and the nodular mass at the bilateral lungs had completely disappeared after 7 weeks.
American Psychological Association (APA)
Obata, Kyoichi& Okui, Tatsuo& Kishimoto, Koji& Ibaragi, Soichiro& Sasaki, Akira. 2020. Methotrexate-Associated Lymphoproliferative Disorder Developed Ectopically in the Maxillary Gingiva and Bilateral Lungs. Case Reports in Medicine،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1148485
Modern Language Association (MLA)
Obata, Kyoichi…[et al.]. Methotrexate-Associated Lymphoproliferative Disorder Developed Ectopically in the Maxillary Gingiva and Bilateral Lungs. Case Reports in Medicine No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1148485
American Medical Association (AMA)
Obata, Kyoichi& Okui, Tatsuo& Kishimoto, Koji& Ibaragi, Soichiro& Sasaki, Akira. Methotrexate-Associated Lymphoproliferative Disorder Developed Ectopically in the Maxillary Gingiva and Bilateral Lungs. Case Reports in Medicine. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1148485
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148485