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Huangqi Shengmai Yin Protects against Radiation-Induced Cardiac Fibrosis Injury by Regulating the TGF-β1Smads and MMPs
Joint Authors
Gu, Jing
Liu, Yongqi
Wu, Hongyan
Li, Hailong
Liu, Kai
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Radiation-induced heart damage is considered to be a progressive process of fibrosis.
Emerging evidence has indicated that the Smads and matrix metalloproteinases (MMPs)/tissue inhibitors of MMPs (TIMP) may be involved in radiation-induced cardiac fibrosis (RICF) by regulating the activation of TGF-β1 signaling pathway.
Based on this, the present study was undertaken to characterize the effect of Huangqi Shengmai Yin (HSY) on RICF in a rat model.
Methods.
Precardiac region of rats was irradiated with 25 Gy X-rays, and their myocardial pathology scores in terms of injury and collagen volume fraction (CVF) and the expression levels of fibrotic molecules were detected.
Results.
The pathology scores and CVF in myocardial tissue increased after irradiation, and the expression of TGF-β1, Col1, and Col3 increased.
This change indicated that such irradiation promoted the fibrosis damage in rat hearts.
The damage was accompanied by an increase in the expression of Smad 2, Smad3, Smad4, and MMP14 and a decrease in the expression of Smad 7 and TIMP1.
Administration of HSY weakened the RICF by decreasing pathology score and CVF and decreased the expression of TGF-β1, Col1, and Col3 in irradiated rat hearts.
In addition, Smad2, Smad3, Smad4, and MMP14 were downregulated, while Smad 7 and TIMP1 were upregulated during intervention with HSY.
Conclusions.
The involvement of the TGF-β1/Smads and MMPs/TIMP system in RICF was confirmed.
This study demonstrated, for the first time, that HSY attenuates the effects of RICF in a rat model.
The effect HSY was found to be closely related to the TGF-β1/Smads signaling pathway and MMPs system.
These results suggest that HSY is a prospective drug for clinical treatment of RICF.
American Psychological Association (APA)
Gu, Jing& Liu, Yongqi& Wu, Hongyan& Li, Hailong& Liu, Kai. 2019. Huangqi Shengmai Yin Protects against Radiation-Induced Cardiac Fibrosis Injury by Regulating the TGF-β1Smads and MMPs. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1148506
Modern Language Association (MLA)
Gu, Jing…[et al.]. Huangqi Shengmai Yin Protects against Radiation-Induced Cardiac Fibrosis Injury by Regulating the TGF-β1Smads and MMPs. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1148506
American Medical Association (AMA)
Gu, Jing& Liu, Yongqi& Wu, Hongyan& Li, Hailong& Liu, Kai. Huangqi Shengmai Yin Protects against Radiation-Induced Cardiac Fibrosis Injury by Regulating the TGF-β1Smads and MMPs. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1148506
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148506