Combination Therapy with Nintedanib and Sarilumab for the Management of Rheumatoid Arthritis Related Interstitial Lung Disease
Joint Authors
Sebastiani, Marco
Manfredi, Andreina
Vacchi, Caterina
Salvarani, Carlo
Cerri, Stefania
Cassone, Giulia
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-09
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease characterized by joint and extra-articular involvement.
Among them, interstitial lung disease (ILD) is one of the most common and severe extra-articular manifestations, with a negative impact on both therapeutic approach and overall prognosis.
ILD can occur at any point of the natural history of RA, sometimes before the appearance of joint involvement.
Since no controlled studies are available, the therapeutic approach to RA-ILD is still debated and based on empirical approaches dependent on retrospective studies and case series.
Here, we report the case of a 75-year-old patient affected by RA complicated by ILD successfully treated with a combination therapy of an antifibrotic agent, nintedanib, and an inhibitor of IL-6 receptor, sarilumab.
We obtained a sustained remission of the joint involvement and, simultaneously, a stabilization of the respiratory symptoms and function, with a good safety profile.
To date, this is the first report describing a combination therapy with nintedanib and a disease-modifying antirheumatic drug (DMARD) for the management of RA complicated by ILD.
Future prospective studies are needed to better define efficacy and safety of this approach in the treatment of these subjects.
American Psychological Association (APA)
Vacchi, Caterina& Manfredi, Andreina& Cassone, Giulia& Salvarani, Carlo& Cerri, Stefania& Sebastiani, Marco. 2020. Combination Therapy with Nintedanib and Sarilumab for the Management of Rheumatoid Arthritis Related Interstitial Lung Disease. Case Reports in Medicine،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1148550
Modern Language Association (MLA)
Vacchi, Caterina…[et al.]. Combination Therapy with Nintedanib and Sarilumab for the Management of Rheumatoid Arthritis Related Interstitial Lung Disease. Case Reports in Medicine No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1148550
American Medical Association (AMA)
Vacchi, Caterina& Manfredi, Andreina& Cassone, Giulia& Salvarani, Carlo& Cerri, Stefania& Sebastiani, Marco. Combination Therapy with Nintedanib and Sarilumab for the Management of Rheumatoid Arthritis Related Interstitial Lung Disease. Case Reports in Medicine. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1148550
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148550