Diffuse Neurofibroma in a Patient with Unknown History of NF1

Abstract EN

Malignant peripheral nerve sheath tumor (MPNST) is a rare disease in the parotid gland with a poor prognosis in most cases.

The disease most often develops in the setting of neurofibromatosis type 1 (NF1) but can also occur sporadically.

Herein, we report a rare case of MPNST in the parotid gland, in a patient with no previous history of NF1.

Initial investigations of the patient, which consisted of laboratory investigations, ultrasound imaging of the swelling, fine-needle aspiration (FNA), computed tomography (CT) scan, and magnetic resonance imaging (MRI) of the neck and swelling, were compatible with a benign pleomorphic adenoma of the parotid gland.

However, intraoperatively, the dissection was challenging as the tumor was adherent to the neighboring tissue.

A diagnosis of MPNST arising from a diffuse neurofibroma was established based on clinicopathologic features of the disease.

The patient, who exhibited clinical features compatible with (NF1), proceeded for radiotherapy following surgery to continue his treatment.