Therapeutic Effect and Mechanism Study of Rhodiola wallichiana var. cholaensis Injection to Acute Blood Stasis Using Metabolomics Based on UPLC-QTOF-MS
Joint Authors
Liu, Jinping
Zheng, Jingtong
Li, Pingya
Wang, Fang
Pang, Zhiqiang
Ran, Nan
Guan, Xuewa
Wang, Guoqiang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-03
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
In traditional Chinese medicine theory, blood stasis syndrome (BSS), characterized by blood flow retardation and blood stagnation, is one of the main pathologic mechanisms and clinical syndromes of cardiovascular diseases (CVDs).
Rhodiola wallichiana var.
cholaensis injection (RWCI) is made from dry roots and stems of RWC via the processes of decoction, alcohol precipitation, filtration, and dilution.
Studies indicated the extracts of RWC could alleviate CVDs; however, the mechanism had not been illustrated.
In the present study, the acute blood stasis rat model was established to investigate the pathogenesis of BSS and the therapeutic mechanism of RWCI against BSS.
Hemorheological parameters (whole blood viscosity and plasma viscosity) and inflammatory factors (TNF-α and IL-6) were used to evaluate the success of the BSS rat model and RWCI efficacy.
14 and 33 differential metabolites were identified from plasma and urine samples using the metabolomics approach based on ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.
The results of multivariate analysis displayed that there were significant separations among model, control, and treatment groups, but the high-dose RWCI treatment group was closer to the control group.
9 perturbed metabolic pathways were related to BSS’s development and RWCI intervention.
5 metabolic pathways (arachidonic acid metabolism, linoleic acid metabolism, alpha-linolenic acid metabolism, retinol metabolism, and steroid hormone biosynthesis) showed apparent correlations.
These differential metabolites and perturbed metabolic pathways might provide a novel view to understand the pathogenesis of BSS and the pharmacological mechanism of RWCI.
American Psychological Association (APA)
Ran, Nan& Pang, Zhiqiang& Guan, Xuewa& Wang, Guoqiang& Liu, Jinping& Li, Pingya…[et al.]. 2019. Therapeutic Effect and Mechanism Study of Rhodiola wallichiana var. cholaensis Injection to Acute Blood Stasis Using Metabolomics Based on UPLC-QTOF-MS. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-20.
https://search.emarefa.net/detail/BIM-1148578
Modern Language Association (MLA)
Ran, Nan…[et al.]. Therapeutic Effect and Mechanism Study of Rhodiola wallichiana var. cholaensis Injection to Acute Blood Stasis Using Metabolomics Based on UPLC-QTOF-MS. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-20.
https://search.emarefa.net/detail/BIM-1148578
American Medical Association (AMA)
Ran, Nan& Pang, Zhiqiang& Guan, Xuewa& Wang, Guoqiang& Liu, Jinping& Li, Pingya…[et al.]. Therapeutic Effect and Mechanism Study of Rhodiola wallichiana var. cholaensis Injection to Acute Blood Stasis Using Metabolomics Based on UPLC-QTOF-MS. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-20.
https://search.emarefa.net/detail/BIM-1148578
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148578