Insulin Independence in Newly Diagnosed Type 1 Diabetes Patient following Fenofibrate Treatment

Joint Authors

Buschard, K.
Holm, Laurits J.
Feldt-Rasmussen, Ulla

Source

Case Reports in Medicine

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-3, 3 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-05-15

Country of Publication

Egypt

No. of Pages

3

Main Subjects

Medicine

Abstract EN

A 19-year-old girl was diagnosed with type 1 diabetes and showing polydipsia and polyuria.

She was double autoantibody-positive and had a diabetes-prone tissue type.

She was immediately started on insulin.

Fenofibrate treatment (160 mg daily) was initiated seven days after diagnosis.

The need for insulin quickly declined, and she took her last dose of insulin 19 days after the first dose of fenofibrate, having regained endogenous control of blood glucose concentrations.

She has now been insulin independent for one year and 9 months.

Unstimulated C-peptide has increased by 51% (317 to 479 pmol/l), and IA-2 autoantibody level has decreased by 65% (49 to 17 × 103 arbitrary units).

Fenofibrate is a widely used drug for reducing triglyceride and cholesterol levels.

Fenofibrate reverses and prevents autoimmune diabetes in nonobese diabetic (NOD) mice by increasing the amount of the sphingolipid sulfatide in islets.

Sphingolipid metabolism is otherwise abnormal in the islets at diagnosis of type 1 diabetes.

In conclusion, we describe a 19-year-old patient with classical newly diagnosed type 1 diabetes, which following fenofibrate treatment has been without insulin for 21 months.

American Psychological Association (APA)

Buschard, K.& Holm, Laurits J.& Feldt-Rasmussen, Ulla. 2020. Insulin Independence in Newly Diagnosed Type 1 Diabetes Patient following Fenofibrate Treatment. Case Reports in Medicine،Vol. 2020, no. 2020, pp.1-3.
https://search.emarefa.net/detail/BIM-1148580

Modern Language Association (MLA)

Buschard, K.…[et al.]. Insulin Independence in Newly Diagnosed Type 1 Diabetes Patient following Fenofibrate Treatment. Case Reports in Medicine No. 2020 (2020), pp.1-3.
https://search.emarefa.net/detail/BIM-1148580

American Medical Association (AMA)

Buschard, K.& Holm, Laurits J.& Feldt-Rasmussen, Ulla. Insulin Independence in Newly Diagnosed Type 1 Diabetes Patient following Fenofibrate Treatment. Case Reports in Medicine. 2020. Vol. 2020, no. 2020, pp.1-3.
https://search.emarefa.net/detail/BIM-1148580

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1148580