A Rare Presentation of Possible Disseminated Histoplasmosis with Adrenal Insufficiency Leading to Adrenal Crisis in an Immunocompetent Adult: A Case Report
Joint Authors
Jayathilake, Wanasinghe Arachchilage Praneeth Prabash
Kumarihamy, Kulatunga Wijekoon Mudiyanselage Pramitha Prabhashini
Ralapanawa, Dissanayake Mudiyanselage Priyantha Udaya Kumara
Jayalath, Thilak
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Histoplasmosis is caused by Histoplasma capsulatum, and commonly it causes an asymptomatic illness.
Although Histoplasma is the commonest organism to infect adrenal glands, disseminated histoplasmosis in an immune-competent host leading to adrenal insufficiency is rare in current literature.
Here, we report a case of possible disseminated histoplasmosis leading to adrenal crisis in a young Asian immunocompetent male.
A 42-year-old Sri Lankan male with noninsulin-dependent diabetes mellitus presented with constitutional symptoms and feverishness for three weeks’ duration.
He was found to have hepatosplenomegaly with bilateral adrenal masses and pancytopenia.
One week later, he developed severe vomiting and hemodynamic collapse and was found to have suppressed adrenal functions.
Ultrasound-guided biopsy of adrenals showed fungal spores morphologically similar to Histoplasma.
He was started on oral itraconazole and adrenal replacement therapy.
He improved symptomatically with treatment and currently is on regular clinic follow-up with a plan to continue antifungal therapy for at least one year to prevent a relapse.
Fungal infections, especially histoplasmosis, need to be considered in all immunocompetent patients with compatible history and bilateral adrenal masses.
Adrenal insufficiency needs to be promptly diagnosed and treated to prevent Addisonian crisis in these patients.
American Psychological Association (APA)
Jayathilake, Wanasinghe Arachchilage Praneeth Prabash& Kumarihamy, Kulatunga Wijekoon Mudiyanselage Pramitha Prabhashini& Ralapanawa, Dissanayake Mudiyanselage Priyantha Udaya Kumara& Jayalath, Thilak. 2020. A Rare Presentation of Possible Disseminated Histoplasmosis with Adrenal Insufficiency Leading to Adrenal Crisis in an Immunocompetent Adult: A Case Report. Case Reports in Medicine،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1148656
Modern Language Association (MLA)
Jayathilake, Wanasinghe Arachchilage Praneeth Prabash…[et al.]. A Rare Presentation of Possible Disseminated Histoplasmosis with Adrenal Insufficiency Leading to Adrenal Crisis in an Immunocompetent Adult: A Case Report. Case Reports in Medicine No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1148656
American Medical Association (AMA)
Jayathilake, Wanasinghe Arachchilage Praneeth Prabash& Kumarihamy, Kulatunga Wijekoon Mudiyanselage Pramitha Prabhashini& Ralapanawa, Dissanayake Mudiyanselage Priyantha Udaya Kumara& Jayalath, Thilak. A Rare Presentation of Possible Disseminated Histoplasmosis with Adrenal Insufficiency Leading to Adrenal Crisis in an Immunocompetent Adult: A Case Report. Case Reports in Medicine. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1148656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148656