Salvia officinalis, Rosmarinic and Caffeic Acids Attenuate Neuropathic Pain and Improve Function Recovery after Sciatic Nerve Chronic Constriction in Mice
Joint Authors
El Gabbas, Zineb
Bezza, Kenza
Laadraoui, Jawad
Ait Laaradia, Mehdi
Kebbou, Aaziz
Oufquir, Sara
Boukhira, Abderrahman
Aboufatima, Rachida
Chait, Abderrahman
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-24
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The leaves of Salvia officinalis L.
have a traditional reputation for the management of pain in Morocco.
This study was conducted to investigate the curative effects of Salvia officinalis (SO) and its major constituents Rosmarinic (ROS) and Caffeic acids (CAF) on peripheral neuropathic pain in mice.
Chronic constriction injury (CCI) was induced in mice, and neuropathic pain behaviors tests were evaluated by mechanical, chemical, thermal sensation tests and functional recovery of the sciatic nerve at different time intervals, i.e., (day 0, 1, 7, 14, and 21).
Ethanolic extract of SO (100 and 200 mg/kg, p.o.), ROS (10 and 20 mg/kg, i.p.), CAF (30 and 40 mg/kg, i.p.), and CLOM (5 mg/kg, i.p., a positive control) was given for 21 days after surgery.
Hematological and biochemical parameters were also measured as well as histopathological analysis.
CCI produced significant development in mechanical and thermal hyperalgesia, cold allodynia, and rise in the sciatic functional index in mice.
Chronic treatments with SO extract, ROS, CAF, and CLOM for 3 weeks significantly increased mechanical sensibility, cold, and thermal withdrawal latency and enhanced functional recovery of the injured nerve.
The same treatments remarkably ameliorated hematological parameters and did not alter biochemical levels.
The histopathological findings had revealed the protective effect of SO, ROS, and CAF against the CCI-induced damage.
Our data support the use of SO in folk medicine to alleviate pain.
Their main phenolic constituents could be promising antineuropathic compounds, which may be attributed to their biological activities including anti-inflammatory, antioxidant, and neuroprotective effects.
SO leaves may be a good candidate to treat neuropathic pain.
American Psychological Association (APA)
El Gabbas, Zineb& Bezza, Kenza& Laadraoui, Jawad& Ait Laaradia, Mehdi& Kebbou, Aaziz& Oufquir, Sara…[et al.]. 2019. Salvia officinalis, Rosmarinic and Caffeic Acids Attenuate Neuropathic Pain and Improve Function Recovery after Sciatic Nerve Chronic Constriction in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1148668
Modern Language Association (MLA)
El Gabbas, Zineb…[et al.]. Salvia officinalis, Rosmarinic and Caffeic Acids Attenuate Neuropathic Pain and Improve Function Recovery after Sciatic Nerve Chronic Constriction in Mice. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1148668
American Medical Association (AMA)
El Gabbas, Zineb& Bezza, Kenza& Laadraoui, Jawad& Ait Laaradia, Mehdi& Kebbou, Aaziz& Oufquir, Sara…[et al.]. Salvia officinalis, Rosmarinic and Caffeic Acids Attenuate Neuropathic Pain and Improve Function Recovery after Sciatic Nerve Chronic Constriction in Mice. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1148668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148668