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Ezetimibe: An Unusual Suspect in Angioedema
Joint Authors
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-27
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
We describe a case of new onset angioedema likely due to Ezetimibe therapy in an elderly patient with a prior history of drug-induced bradykinin reactions who had been on the medication for multiple years.
This is the second reported incidence of Ezetimibe-associated angioedema in literature.
A 90-year-old African American female presented with angioedema of the face and oral mucosa with associated difficulty speaking developing hours after taking Ezetimibe 10 mg PO.
She denied adding any new or unusual foods to her diet.
A thorough clinical history determined Ezetimibe was the likely culprit.
Ezetimibe was immediately discontinued.
The swelling subsided after administration of methylprednisolone 125 mg, epinephrine 1 mg/mL, injection 0.3 mL, diphenhydramine 25 mg, and famotidine 20 mg BID within 48 hours.
The patient’s C1 esterase inhibitor level was measured to be within normal limits.
Food panel allergy testing showed very low or undetectable IgE levels in all categories.
Based on the limited reports in literature and our current case, we conclude that there is a likely association of angioedema with Ezetimibe.
The mechanism, however, is unknown since it is not related to bradykinin or mast cell-mediated activation.
Clinicians should advise patients taking Ezetimibe to report any swelling of the lips, face, and tongue and to immediately discontinue its use if these signs are present.
American Psychological Association (APA)
Lu, Tiffany& Grewal, Tarundeep. 2020. Ezetimibe: An Unusual Suspect in Angioedema. Case Reports in Medicine،Vol. 2020, no. 2020, pp.1-3.
https://search.emarefa.net/detail/BIM-1148701
Modern Language Association (MLA)
Lu, Tiffany& Grewal, Tarundeep. Ezetimibe: An Unusual Suspect in Angioedema. Case Reports in Medicine No. 2020 (2020), pp.1-3.
https://search.emarefa.net/detail/BIM-1148701
American Medical Association (AMA)
Lu, Tiffany& Grewal, Tarundeep. Ezetimibe: An Unusual Suspect in Angioedema. Case Reports in Medicine. 2020. Vol. 2020, no. 2020, pp.1-3.
https://search.emarefa.net/detail/BIM-1148701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148701