Protective Effect of the Total Triterpenes of Euscaphis konishii Hayata Pericarp on Bacillus Calmette-Guérin Plus Lipopolysaccharide-Induced Liver Injury
Joint Authors
Huang, Wei
Ding, Hui
Chen, Lu-yao
Ni, Lin
Ruan, Yi-fang
Zou, Xiao-xing
Ye, Min
Zou, Shuang-quan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-04
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Background.
Liver injury has been recognized as a primary cause of hepatic morbidity and mortality.
Euscaphis konishii Hayata, also called Euscaphis fukienensis Hsu, is usually used as a detumescent and analgesic agent to improve liver function in South China, but its mechanism of action and chemical composition are unclear.
Objective.
The main aim of the study was to investigate the constituent and potential hepatoprotective mechanism of the total triterpenes of E.
konishii pericarp (TTEP).
Methods.
The constituent of TTEP was analyzed by a series of silica gel column to get single compounds and then identified by NMR and MS.
In vitro assays were conducted to test the free radical scavenging activity of TTEP.
The BCG/LPS-induced immunological livery injury mice model was established to clarify the hepatoprotective effect of TTEP in vivo.
Results.
8 pentacyclic triterpene acids were separated and identified by NMR and MS.
TTEP treatment (50, 100, and 200 mg/Kg) improved the immune function of the BCG/LPS-infected mice, dose-dependently alleviated the BCG/LPS-induced inflammation and oxidative stress, and ameliorated the hepatocyte apoptosis in the liver tissue.
Conclusion.
The pericarp of E.
konishii may be further considered as a potent natural food for liver disease treatment.
American Psychological Association (APA)
Huang, Wei& Ding, Hui& Chen, Lu-yao& Ni, Lin& Ruan, Yi-fang& Zou, Xiao-xing…[et al.]. 2019. Protective Effect of the Total Triterpenes of Euscaphis konishii Hayata Pericarp on Bacillus Calmette-Guérin Plus Lipopolysaccharide-Induced Liver Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1148710
Modern Language Association (MLA)
Huang, Wei…[et al.]. Protective Effect of the Total Triterpenes of Euscaphis konishii Hayata Pericarp on Bacillus Calmette-Guérin Plus Lipopolysaccharide-Induced Liver Injury. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1148710
American Medical Association (AMA)
Huang, Wei& Ding, Hui& Chen, Lu-yao& Ni, Lin& Ruan, Yi-fang& Zou, Xiao-xing…[et al.]. Protective Effect of the Total Triterpenes of Euscaphis konishii Hayata Pericarp on Bacillus Calmette-Guérin Plus Lipopolysaccharide-Induced Liver Injury. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1148710
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148710