Uterine Carcinosarcoma with Alpha-Fetoprotein-Producing Hepatoid Component: A Case Report and Literature Review
Joint Authors
Lee, Jacqueline H. S.
Chan, Vicky T. C.
Yu, Mei-yung
Li, Joshua J. X.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A 67-year-old woman presented with postmenopausal vaginal bleeding.
Full body imaging demonstrated an intrauterine mass with deep myometrial invasion but no nodal or other metastatic disease.
Uterine curettage was performed.
Histologically, the tumor was an endometrioid adenocarcinoma with sarcomatous element and a hepatoid component, the latter was immunohistochemically positive for alpha-fetoprotein, HepPar-1, and arginase-1.
The patient underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy.
Serum alpha-fetoprotein level decreased from 31896 ug/l preoperatively to 2063 ug/l postoperatively.
Eight weeks later, a rise in serum alpha-fetoprotein was detected, and a biopsy-proven vaginal recurrence was diagnosed.
Palliative chemotherapy led to tumor shrinkage and a concurrent decrease in the serum alpha-fetoprotein level.
A rise in serum alpha-fetoprotein, refractory to second-line chemotherapy, was accompanied by subsequent development of ureteric obstruction, ascites, and radiological evidence of peritoneal metastases.
This is an unusual case of uterine carcinosarcoma with an alpha-fetoprotein-producing hepatoid adenocarcinoma component.
Serum alpha-fetoprotein level corresponds to disease recurrence and progression.
American Psychological Association (APA)
Li, Joshua J. X.& Lee, Jacqueline H. S.& Chan, Vicky T. C.& Yu, Mei-yung. 2018. Uterine Carcinosarcoma with Alpha-Fetoprotein-Producing Hepatoid Component: A Case Report and Literature Review. Case Reports in Pathology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1148733
Modern Language Association (MLA)
Li, Joshua J. X.…[et al.]. Uterine Carcinosarcoma with Alpha-Fetoprotein-Producing Hepatoid Component: A Case Report and Literature Review. Case Reports in Pathology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1148733
American Medical Association (AMA)
Li, Joshua J. X.& Lee, Jacqueline H. S.& Chan, Vicky T. C.& Yu, Mei-yung. Uterine Carcinosarcoma with Alpha-Fetoprotein-Producing Hepatoid Component: A Case Report and Literature Review. Case Reports in Pathology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1148733
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148733