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Membranoproliferative Glomerulonephritis Associated with Nivolumab Therapy
Joint Authors
Cruz-Whitley, Jessica
Giehl, Nolan
Jen, Kuang-Yu
Young, Brian
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-24
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Nivolumab is an immune checkpoint inhibitor that targets programmed death-1 on T cells and is designed to amplify an immunologic reaction against cancer cells.
However, upregulation of the immune system with checkpoint inhibition is nonspecific, and it can be associated with certain renal side effects, the best documented of which is acute tubulointerstitial nephritis.
We present a unique case of a patient with acute kidney injury associated with nephrotic syndrome shortly after starting nivolumab therapy for metastatic anal carcinoma.
Subsequent renal biopsy revealed membranoproliferative glomerulonephritis (MPGN).
We believe this represents the first reported direct case of nivolumab-associated MPGN.
As immunotherapy becomes more widely used in cancer treatment, particular attention must be paid to possible consequences of immune checkpoint inhibitors.
American Psychological Association (APA)
Cruz-Whitley, Jessica& Giehl, Nolan& Jen, Kuang-Yu& Young, Brian. 2020. Membranoproliferative Glomerulonephritis Associated with Nivolumab Therapy. Case Reports in Nephrology،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1148741
Modern Language Association (MLA)
Cruz-Whitley, Jessica…[et al.]. Membranoproliferative Glomerulonephritis Associated with Nivolumab Therapy. Case Reports in Nephrology No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1148741
American Medical Association (AMA)
Cruz-Whitley, Jessica& Giehl, Nolan& Jen, Kuang-Yu& Young, Brian. Membranoproliferative Glomerulonephritis Associated with Nivolumab Therapy. Case Reports in Nephrology. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1148741
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148741