Primary Small Cell Carcinoma of the Hypopharynx: A Report of Two Cases and Review of Nine Additional Cases
Joint Authors
Nakahira, Mitsuhiko
Sugasawa, Masashi
Kuba, Kiyomi
Matsumura, Satoko
Source
Case Reports in Otolaryngology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Two patients with primary small cell carcinoma (SmCC) of the hypopharynx, an extremely rare site for the occurrence of SmCC, are reported and nine additional well-documented cases are reviewed.
Methods.
Case report and review of the literature concerning primary SmCC of the hypopharynx.
Results.
On the final analysis, we reviewed eleven cases of primary SmCC of the hypopharynx.
The tumors contained mixed elements of SmCC and squamous cell carcinoma (SCC) in six (55%) of eleven patients.
Out of eleven patients, two patients had distant metastasis at the initial presentation.
Even though nine patients presented with locoregional disease, development of distant metastasis after treatment was seen in five patients (56%), whereas there was no report of treatment failure on the primary site.
To achieve more than two-year survival, patients should have received more than 4 cycles of chemotherapy.
Conclusion.
We report two cases of primary SmCC of the hypopharynx with a review of the literature.
In more than half of the cases, combined carcinomas with SCC are seen.
Because this tumor has a strong propensity for distant metastasis even in patients with clinically localized tumor, new powerful systemic agents should be explored.
American Psychological Association (APA)
Nakahira, Mitsuhiko& Kuba, Kiyomi& Matsumura, Satoko& Sugasawa, Masashi. 2017. Primary Small Cell Carcinoma of the Hypopharynx: A Report of Two Cases and Review of Nine Additional Cases. Case Reports in Otolaryngology،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1148757
Modern Language Association (MLA)
Nakahira, Mitsuhiko…[et al.]. Primary Small Cell Carcinoma of the Hypopharynx: A Report of Two Cases and Review of Nine Additional Cases. Case Reports in Otolaryngology No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1148757
American Medical Association (AMA)
Nakahira, Mitsuhiko& Kuba, Kiyomi& Matsumura, Satoko& Sugasawa, Masashi. Primary Small Cell Carcinoma of the Hypopharynx: A Report of Two Cases and Review of Nine Additional Cases. Case Reports in Otolaryngology. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1148757
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148757