CD5-Positive Intravascular Large B-Cell Lymphoma in a Patient with Wilson’s Disease: Case Report and Review of the Literature
Joint Authors
Zhang, Xinmin
Gupta, Neha
Katte Carreon, Chrystalle
Sen, Filiz
Farmer, Peter
Sheikh-Fayyaz, Silvat
Haghi, Nina
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Intravascular large B-cell lymphoma (IVLBCL) is a rare extra-nodal B-cell lymphoma that proliferates within small/intermediate blood vessels and capillaries while sparing large blood vessels and organ parenchyma.
Clinical presentation is highly variable and may include B symptoms, neurological deficits, and/or cutaneous findings.
The diagnosis of IVLBCL is difficult due to multiorgan involvement and nonspecific symptoms.
We describe the case of a 68-year-old male who presented with progressive weakness, confusion, and falls.
He had a past medical history of liver cirrhosis secondary to Wilson’s disease.
Physical exam and laboratory results revealed a lethargic man with jaundice, hepatic encephalopathy, and abnormal liver/kidney function tests.
He expired after a short hospital course in the setting of hepatic and renal failure.
Postmortem examination revealed large neoplastic lymphoid cells involving multiple organ blood vessels; however skin and neurologic involvement was absent.
The neoplastic cells demonstrated B-cells positive for CD5, rendering a diagnosis of IVLBCL.
Our case represents the occurrence of IVLBCL with CD5-positivity in a patient with Wilson’s disease, diagnosed at autopsy demonstrating the challenging nature of diagnosing IVLBCL.
American Psychological Association (APA)
Gupta, Neha& Katte Carreon, Chrystalle& Sen, Filiz& Farmer, Peter& Zhang, Xinmin& Sheikh-Fayyaz, Silvat…[et al.]. 2018. CD5-Positive Intravascular Large B-Cell Lymphoma in a Patient with Wilson’s Disease: Case Report and Review of the Literature. Case Reports in Pathology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1148776
Modern Language Association (MLA)
Gupta, Neha…[et al.]. CD5-Positive Intravascular Large B-Cell Lymphoma in a Patient with Wilson’s Disease: Case Report and Review of the Literature. Case Reports in Pathology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1148776
American Medical Association (AMA)
Gupta, Neha& Katte Carreon, Chrystalle& Sen, Filiz& Farmer, Peter& Zhang, Xinmin& Sheikh-Fayyaz, Silvat…[et al.]. CD5-Positive Intravascular Large B-Cell Lymphoma in a Patient with Wilson’s Disease: Case Report and Review of the Literature. Case Reports in Pathology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1148776
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148776